抑制 cGAS-STING 通路：有助于治疗脑缺血/再灌注损伤。

IF 5.9 2区医学 Q2 CELL BIOLOGY

Neural Regeneration Research Pub Date : 2025-07-01 Epub Date: 2024-07-10 DOI:10.4103/NRR.NRR-D-24-00015

Hang Yang, Yulei Xia, Yue Ma, Mingtong Gao, Shuai Hou, Shanshan Xu, Yanqiang Wang

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引用次数: 0

摘要

摘要：cGAS-STING通路在心脏、肝脏、大脑和肾脏的缺血再灌注损伤中发挥着重要作用，但其在脑缺血再灌注损伤中的作用和机制尚未得到系统的研究。在此，我们概述了 cGAS-STING 通路的组成成分，然后分析了它在脑缺血再灌注损伤后的自噬、铁变态反应、细胞热解、钙平衡失调、炎症反应、血脑屏障破坏、小胶质细胞转化和补体系统激活中的作用。我们进一步分析了 cGAS- STING 通路抑制剂在治疗脑缺血再灌注损伤中的价值，并得出结论：该通路可通过多种机制调节脑缺血再灌注损伤。抑制 cGAS-STING 通路可能有助于治疗脑缺血再灌注损伤。

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Inhibition of the cGAS-STING pathway: contributing to the treatment of cerebral ischemia-reperfusion injury.

The cGAS-STING pathway plays an important role in ischemia-reperfusion injury in the heart, liver, brain, and kidney, but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically reviewed. Here, we outline the components of the cGAS-STING pathway and then analyze its role in autophagy, ferroptosis, cellular pyroptosis, disequilibrium of calcium homeostasis, inflammatory responses, disruption of the blood-brain barrier, microglia transformation, and complement system activation following cerebral ischemia-reperfusion injury. We further analyze the value of cGAS-STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple mechanisms. Inhibition of the cGAS-STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

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来源期刊

Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES

CiteScore

8.00

自引率

9.80%

发文量

515

审稿时长

1.0 months

期刊介绍： Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.