西咪替丁不改变健康志愿者游离不变卡托普利的药代动力学和生物学效应。

Journal de pharmacologie Pub Date : 1986-07-01

C Richer, M Bah, M Cadilhac, C Thuillez, J F Giudicelli

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引用次数: 0

摘要

本文研究了西咪替丁(单次或多次给药)对正常健康志愿者游离不变卡托普利血浆水平、药代动力学参数和血浆转化酶抑制作用的影响。西咪替丁既不影响卡托普利的药代动力学参数，也不影响其生物学效应，提示当西咪替丁同时给药时，不需要改变卡托普利的剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cimetidine does not alter free unchanged captopril pharmacokinetics and biological effects in healthy volunteer.

The effects of cimetidine (single or repeated administration) on free unchanged captopril plasma levels, pharmacokinetic parameters and plasma converting enzyme inhibitory effects have been investigated in normal healthy volunteers. Cimetidine affected neither captopril pharmacokinetic parameters nor its biological effects, suggesting that no change in captopril dosing is necessary when cimetidine is co-administered.

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Journal de pharmacologie

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