从紫檀种子中提取的新的二萜类化合物

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-07-06 DOI:10.1016/j.phytol.2024.06.008

Yue-ping Lan, Wen-jian Gu, Ming Yang, Pu-Zhao Zhang

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引用次数: 0

摘要

从紫檀种子中分离出了三种未曾描述过的二萜类化合物。这些化合物的结构是通过广泛的光谱技术阐明的。评估了所有分离出的化合物对脂多糖诱导的 BV-2 微神经胶质细胞一氧化氮（NO）产生的功效。化合物 1 能明显抑制一氧化氮的产生，其 IC50 值为 7.18 ± 0.40 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

New cassane diterpenoids from the seeds of Pterolobium macropterum

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New cassane diterpenoids from the seeds of Pterolobium macropterum

Three undescribed cassane diterpenoids were isolated from the seeds of Pterolobium macropterum. The structures of these compounds were elucidated based on the extensive spectroscopic techniques. All isolated compounds were evaluated for their efficacy on the lipopolysaccharide induced nitric oxide (NO) production in BV-2 microglial cells. Compound 1 could significantly inhibited the production of NO with IC₅₀ value of 7.18 ± 0.40 μM.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.