体外冲击波疗法对培养的马脐带血间充质基质细胞免疫调节和抗炎特性的影响。

IF 0.8 Q3 VETERINARY SCIENCES

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2024-07-01

Andrés Giraldo, Thomas G Koch, Pavneesh Madan, Sarah Lepage, Gabrielle Monteith, Amir H Alizadeh, Andy Tran, Narman Mortagy, Judith B Koenig

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引用次数: 0

摘要

关于体外冲击波治疗（ESWT）对马脐带血间充质基质细胞（CB-MSCs）的应激反应、免疫调节和抗炎特性的影响还存在知识空白。本研究的目的是调查经 ESWT 处理后的 CB-MSCs 是否存在细胞氧化应激、炎症反应和生长因子的产生。我们假设，与未经治疗的 CB-MSCs 相比，接受 ESWT 治疗的 CB-MSCs 将经历更高水平的细胞应激反应，并产生更多的抗炎细胞因子和生长因子。

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Effect of extracorporeal shockwave therapy on the immunomodulatory and anti-inflammatory properties of cultured equine umbilical cord blood mesenchymal stromal cells.

There is a knowledge gap regarding the effect of extracorporeal shockwave treatment (ESWT) on the stress response and immunomodulatory and anti-inflammatory properties of equine umbilical cord blood mesenchymal stromal cells (CB-MSCs). The objective of this study was to investigate the presence of cellular oxidative stress, inflammatory response, and production of growth factors in CB-MSCs after treatment with ESWT. We hypothesized that CB-MSCs treated with ESWT will experience higher levels of cellular stress and increased production of anti-inflammatory cytokines and growth factors compared to untreated CB-MSCs.

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Canadian journal of veterinary research = Revue canadienne de recherche veterinaire

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