在病理生理条件下利用天然产品靶向铁蛋白沉积。

IF 4.8 2区 医学 Q1 TOXICOLOGY
Daheng Zheng, Shikai Jin, Pu-Ste Liu, Jianping Ye, Xin Xie
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引用次数: 0

摘要

铁变态反应是由铁介导的脂质过氧化物积累诱发的一种细胞死亡形式。铁变态反应参与不同的病理生理状况为潜在的治疗干预提供了新的视角。天然产物在药物发现和再利用方面的意义已得到广泛认可,它们通过靶向不同的铁变态反应参与者,在调节铁变态反应方面显示出巨大的前景。在这篇综述中,我们讨论了铁变态反应的调控机制及其在不同病理条件下的影响。我们剖析了在癌症、缺血/再灌注、神经退行性疾病、急性肾损伤、肝损伤和心肌病中天然产物与铁蛋白沉积之间的相互作用,重点是铁蛋白沉积与疾病靶向性的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Targeting ferroptosis by natural products in pathophysiological conditions

Targeting ferroptosis by natural products in pathophysiological conditions

Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement of ferroptosis in different pathophysiological conditions has offered new perspectives on potential therapeutic interventions. Natural products, which are widely recognized for their significance in drug discovery and repurposing, have shown great promise in regulating ferroptosis by targeting various ferroptosis players. In this review, we discuss the regulatory mechanisms of ferroptosis and its implications in different pathological conditions. We dissect the interactions between natural products and ferroptosis in cancer, ischemia/reperfusion, neurodegenerative diseases, acute kidney injury, liver injury, and cardiomyopathy, with an emphasis on the relevance of ferroptosis players to disease targetability.

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来源期刊
Archives of Toxicology
Archives of Toxicology 医学-毒理学
CiteScore
11.60
自引率
4.90%
发文量
218
审稿时长
1.5 months
期刊介绍: Archives of Toxicology provides up-to-date information on the latest advances in toxicology. The journal places particular emphasis on studies relating to defined effects of chemicals and mechanisms of toxicity, including toxic activities at the molecular level, in humans and experimental animals. Coverage includes new insights into analysis and toxicokinetics and into forensic toxicology. Review articles of general interest to toxicologists are an additional important feature of the journal.
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