探索沉积在带电晕的多孔复合聚乳酸/聚(ε-己内酯)基底上的聚电解质多层膜，用于增强药物输送系统

IF 2.9 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Transactions on Dielectrics and Electrical Insulation Pub Date : 2024-07-05 DOI:10.1109/TDEI.2024.3423050

Temenuzhka Yovcheva;Asya Viraneva;Maria Marudova;Aleksandar Grigorov

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引用次数: 0

摘要

研究了沉积在多孔复合聚乳酸（PDLA）/聚( $\varepsilon $ -己内酯)（PEC）基底上的聚电解质多层膜（PEMs）。这些基板通过电晕放电充电。研究了归一化表面电势与带电基底存储时间的关系。逐层（LbL）技术实现了基底上的多层沉积。模型药物盐酸苄达明（Benz）被载入壳聚糖层。研究了药物在生理盐水缓冲液中的释放动力学，并用分光光度法对释放量进行了量化。

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查看原文本刊更多论文

Exploring Polyelectrolyte Multilayers Deposited on Corona-Charged Porous Composite Polylactic Acid/Poly(ε-Caprolactone) Substrates for Enhanced Drug Delivery Systems

Polyelectrolyte multilayers (PEMs) deposited on porous composite poly-lactic acid (PDLA)/poly(

$\varepsilon $

-caprolactone) (PEC) substrates are investigated. The substrates are charged with a corona discharge. The dependence of the normalized surface potentials on the storage time of the charged substrates is studied. Layer-by-layer (LbL) technique enables multilayer deposition on the substrates. A model drug Benzydamine hydrochloride (Benz) is loaded into the chitosan layers. A study of the drug release kinetics in saline buffer is carried out and the amount released is quantified spectrophotometrically.

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来源期刊

IEEE Transactions on Dielectrics and Electrical Insulation 工程技术-工程：电子与电气

CiteScore

6.00

自引率

22.60%

发文量

309

审稿时长

5.2 months

期刊介绍： Topics that are concerned with dielectric phenomena and measurements, with development and characterization of gaseous, vacuum, liquid and solid electrical insulating materials and systems; and with utilization of these materials in circuits and systems under condition of use.