揭示κ-卡拉胶水凝胶的溶胀行为:成分和生理环境对药物输送潜力的影响

IF 5.9 3区 工程技术 Q1 CHEMISTRY, MULTIDISCIPLINARY
Emad Mozaffari, Bahareh Tanhaei, Maryam Khajenoori, Saeedeh Movaghar Khoshkho
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引用次数: 0

摘要

本研究旨在开发一种基于卡拉胶和琼脂并负载四环素(TC)的可生物降解水凝胶伤口敷料薄膜,该薄膜具有很强的抗菌性能并能加速伤口愈合。研究了κ-卡拉胶/琼脂和负载四环素的水凝胶薄膜的膨胀行为,重点考察了水凝胶在各种生理液体中的功效,以及多糖比例、交联剂浓度和表面活性剂浓度的影响。结果表明,多糖比例对水凝胶的溶胀能力有显著影响,琼脂与κ-卡拉胶的比例为 1:1,溶胀度最高,达到 1386%。加入氯化钾作为交联剂后,溶胀能力提高到 1713%。此外,表面活性剂的浓度也会影响溶胀行为,浓度越高,亲水性和溶胀性越强。水凝胶在不同生理液体中的溶胀性能各不相同,在去离子水(DIW)和模拟伤口液(SWF)中分别观察到最高和最低的溶胀。在去离子水和磷酸盐缓冲盐水(PBS)中的溶胀过程表现出二阶动力学,而在 SWF 中则观察到非菲克扩散机制。κC/AG/TC水凝胶薄膜的药物释放受其溶胀能力和介质pH值的控制。此外,还研究了水凝胶的机械性能、抗菌活性和水蒸气渗透性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unveiling the swelling behavior of κ-carrageenan hydrogels: Influence of composition and physiological environment on drug delivery potential
This study aims to develop a biodegradable hydrogel wound dressing film based on carrageenan and agar loaded with tetracycline (TC), which exhibits high antibacterial properties and accelerates wound healing. The swelling behavior of κ-carrageenan/agar and tetracycline-loaded hydrogel films was examined, with a focus on the hydrogel’s efficacy in various physiological fluids, as well as the effects of polysaccharide ratio, cross-linker concentration, and surfactant concentration. The results revealed that the polysaccharide ratio significantly influenced the hydrogel swelling capacity of hydrogel, and a 1:1 ratio of agar to κ-carrageenan achieved the highest swelling degree of 1386 %. Addition of KCl, as a cross-linker, increased swelling capacity to 1713 %. Furthermore, surfactant concentration also influenced swelling behavior, and higher concentrations resulted in an increase in hydrophilicity and swelling. Hydrogel swelling performance varied across physiological fluids, with the highest and lowest swellings observed in deionized water (DIW) and simulated wound fluid (SWF), respectively. The swelling process in DIW and phosphate buffered saline (PBS) exhibited second-order kinetics, whereas non-Fickian diffusion mechanisms were observed in SWF. The drug release of the κC/AG/TC hydrogel film was controlled by its swelling capacity and the pH of medium. The hydrogels’ mechanical properties, antibacterial activity, and water vapor permeability were also investigated.
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来源期刊
CiteScore
10.40
自引率
6.60%
发文量
639
审稿时长
29 days
期刊介绍: Journal of Industrial and Engineering Chemistry is published monthly in English by the Korean Society of Industrial and Engineering Chemistry. JIEC brings together multidisciplinary interests in one journal and is to disseminate information on all aspects of research and development in industrial and engineering chemistry. Contributions in the form of research articles, short communications, notes and reviews are considered for publication. The editors welcome original contributions that have not been and are not to be published elsewhere. Instruction to authors and a manuscript submissions form are printed at the end of each issue. Bulk reprints of individual articles can be ordered. This publication is partially supported by Korea Research Foundation and the Korean Federation of Science and Technology Societies.
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