伴侣蛋白帮助 TACkle 噬菌体感染

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-07-10 DOI:10.1016/j.chom.2024.06.009

Shally R. Margolis, Alexander J. Meeske

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引用次数: 0

摘要

细菌已经进化出了抗病毒防御系统，但感知和阻止感染的机制仍在研究之中。在本期《细胞宿主与amp; 微生物》（Cell Host & Microbe）杂志上，Mets、Kurata、Ernits 等人描述了细菌毒素-抗毒素相关伴侣蛋白如何直接感知噬菌体蛋白，从而释放毒素活性以防止感染。

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Chaperones help TACkle phage infection

Bacteria have evolved anti-viral defenses, but the mechanisms of sensing and stopping infection are still under investigation. In this issue of Cell Host & Microbe, Mets, Kurata, Ernits et al. describe how direct sensing of a phage protein by a bacterial toxin-antitoxin-associated chaperone unleashes toxin activity to prevent infection.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.