鸡局部肢体灌注后的血浆和组织阿米卡星浓度。

IF 0.6 4区 农林科学 Q3 VETERINARY SCIENCES
Cameron Ratliff, Lorelei Clarke, Heather K Knych, Samantha L Morello, Christoph Mans
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引用次数: 0

摘要

静脉区域肢体灌注(IVRLP)已被用于治疗荚膜皮炎和肢体远端感染,这两种疾病是禽类发病的重要原因。这种静脉给药技术旨在达到较高的药物组织浓度,同时将全身毒性反应降至最低。阿米卡星是兽医常用的 IVRLP 药物,但在鸟类中的用药剂量指南尚未制定。本研究旨在确定在健康的无水蛋鸡(Gallus gallus domesticus)体内单次静脉注射阿米卡星后阿米卡星的组织浓度。鸡只接受单次剂量为 10 毫克/千克阿米卡星的静脉注射,并在治疗后 1 小时(6 只)、12 小时(6 只)和 24 小时(6 只)安乐死,以评估注射腿部组织和滑膜液中的阿米卡星浓度。IVRLP后1小时的平均组织浓度最高(滑膜液 = 153.0 µg/mL,跖垫组织 = 26.05 µg/mL),然后在12小时和24小时后下降。这表明,通过静脉注射阿米卡星,在单次治疗 10 毫克/千克阿米卡星后,组织中的常见细菌分离物可达到最低抑菌浓度。建议每 24 小时进行一次区域肢体灌注,但治疗的最短天数可能取决于病例,并根据治疗反应而有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma and Tissue Amikacin Concentrations Following Regional Limb Perfusion of Chickens (Gallus gallus domesticus).

Intravenous regional limb perfusion (IVRLP) has been used in the treatment of pododermatitis and distal limb infections, which are significant causes of morbidity in avian species. This intravenous drug administration technique is designed to achieve high drug tissue concentrations while minimizing systemic toxic effects. Amikacin is commonly used for IVRLP in veterinary medicine, but dosing guidelines have not been established for its use in birds. The current study aimed to determine the tissue concentration of amikacin after a single IVRLP administration in healthy, euhydrated leghorn hen chickens (Gallus gallus domesticus). Chickens received a single IVRLP dose of 10 mg/kg amikacin and were euthanatized posttreatment at 1 hour (n = 6), 12 hours (n = 6), and 24 hours (n = 6) to assess tissue and synovial fluid concentrations of amikacin in the injected leg. Mean tissue concentrations were highest 1 hour post-IVRLP (synovial fluid = 153.0 µg/mL, metatarsal pad tissue = 26.05 µg/mL) before declining at the 12- and 24-hour time points. This indicates that administration of amikacin via IVRLP can reach minimum inhibitory concentrations of common bacterial isolates in tissues after a single treatment with 10 mg/kg amikacin. Regional limb perfusion every 24 hours is recommended, although the minimum days of treatment may be case dependent and vary based on response to therapy.

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来源期刊
Journal of Avian Medicine and Surgery
Journal of Avian Medicine and Surgery 农林科学-兽医学
CiteScore
0.90
自引率
0.00%
发文量
52
审稿时长
>36 weeks
期刊介绍: The Journal of Avian Medicine and Surgery is an international journal of the medicine and surgery of both captive and wild birds. Published materials include scientific articles, case reports, editorials, abstracts, new research, and book reviews.
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