皮肤深处上皮细胞新陈代谢与慢性皮肤炎症

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-07-09 DOI:10.1016/j.immuni.2024.06.004

Eliana R. Solis, Julie M. Jameson

引用次数: 0

摘要

上皮细胞和免疫细胞的新陈代谢协调会加剧皮肤炎症。在本期《免疫》杂志上，Subudhi 和 Konieczny 等人描述了 HIF1α 如何调节银屑病期间上皮细胞的糖酵解。反过来，乳酸是一种副产品，它增强了 17 型 γδ T 细胞的反应，使炎症性皮肤病持续存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Skin deep: Epithelial cell metabolism and chronic skin inflammation

Skin inflammation is potentiated by coordinated epithelial and immune cell metabolism. In this issue of Immunity, Subudhi and Konieczny et al. delineate how HIF1α regulates epithelial cell glycolysis during psoriasis. In turn, lactate is a byproduct that augments type 17 γδ T cell responses to sustain inflammatory skin disease.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.