高效合成用于细胞再生的糖原合酶激酶-3β 选择性抑制剂 1-azakenpaullone†

IF 2.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

New Journal of Chemistry Pub Date : 2024-06-18 DOI:10.1039/D4NJ00434E

Yujiao Xu, Jianguang Liu, Gengwu Li, Hua Wu, Xinghan Du, Tianhua Ma, Dan Liu and Shibing Tang

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引用次数: 0

摘要

通过以三氯化铟为介导的分子内环化和温和的反应条件，采用两步法合成了糖原合酶激酶-3β的选择性抑制剂--1-Azakenpaullone。这种简洁的合成方法大大提高了合成效率，减少了废物排放。我们期待本研究能促进 1-azakenpaullone 及其类似物在细胞再生和再生医学中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Efficient synthesis of 1-azakenpaullone, a selective inhibitor of glycogen synthase kinase-3β for cellular regeneration†

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Efficient synthesis of 1-azakenpaullone, a selective inhibitor of glycogen synthase kinase-3β for cellular regeneration†

1-Azakenpaullone, a selective inhibitor of glycogen synthase kinase-3β, was synthesized by carrying out a two-step protocol featuring an indium-trichloride-mediated intramolecular cyclization and mild reaction conditions. The concise synthesis showed significantly improved synthetic efficiency and reduced discharge of waste. We expect the present study to boost the applications of 1-azakenpaullone and its analogues in cellular regeneration and regenerative medicine.

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