AlphaFold3 向解码分子行为和生物计算迈出了一步

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-07-08 DOI:10.1038/s41594-024-01350-2

Rohit Roy, Hashim M. Al-Hashimi

引用次数: 0

摘要

AlphaFold 3 是根据序列直接预测复合体三维结构的突破性进展，为生物分子的相互作用提供了洞察力。要将预测扩展到分子行为和功能，就必须从将生物分子视为静态三维结构转变为动态构象组合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

AlphaFold3 takes a step toward decoding molecular behavior and biological computation

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AlphaFold3 takes a step toward decoding molecular behavior and biological computation

AlphaFold 3 represents a breakthrough in predicting the 3D structures of complexes directly from their sequences, offering insights into biomolecular interactions. Extending predictions to molecular behavior and function requires a shift from viewing biomolecules as static 3D structures to dynamic conformational ensembles.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.