氯噻嗪的单斜多晶型。

IF 0.5 Q4 CRYSTALLOGRAPHY

Acta Crystallographica Section E: Crystallographic Communications Pub Date : 2024-06-01 DOI:10.1107/S2056989024006078

Rowan K. H. Brydson , Alan R. Kennedy , F. Di Salvo (Editor)

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引用次数: 0

摘要

本文描述了利尿剂氯噻嗪（6-氯-1,1-二氧代-2H-1,2,4-苯并噻嗪-7-磺酰胺，C7H6ClN3O4S2）的一种新的多晶型。从碱性水溶液中结晶出的这种单斜多晶体，其热力学性质不如已知的三斜多晶体，其分子间氢键只有 N-H⋯O 型，而 P1 型中则有 N-H⋯O 和 N-H⋯N 型氢键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A monoclinic polymorph of chlorothiazide

Accessible from basic aqueous solutions, a new monoclinic polymorph of the diuretic chlorothiazide is described.

A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C₇H₆ClN₃O₄S₂, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H⋯O type intermolecular hydrogen bonds as opposed to the N—H⋯O and N—H⋯N type hydrogen bonds found in the P1 form.

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来源期刊

Acta Crystallographica Section E: Crystallographic Communications Chemistry-Chemistry (all)

CiteScore

1.90

自引率

0.00%

发文量

351

审稿时长

3 weeks

期刊介绍： Acta Crystallographica Section E: Crystallographic Communications is the IUCr''s open-access structural communications journal. It provides a fast, simple and easily accessible publication mechanism for crystal structure determinations of inorganic, metal-organic and organic compounds. The electronic submission, validation, refereeing and publication facilities of the journal ensure rapid and high-quality publication of fully validated structures. The primary article category is Research Communications; these are peer-reviewed articles describing one or more structure determinations with appropriate discussion of the science.