丙戊酸对小鼠肝脏法尼类固醇-X-激活受体及其下游靶点调节作用的随时间变化趋势研究

IF 3.2 4区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Toxicology Mechanisms and Methods Pub Date : 2024-06-18 DOI:10.1080/15376516.2024.2364192

Amir Saamaan Fattahi, Azadeh Khalili, Seyed Ali Hashemi, Parvaneh Najafizadeh, Roham Mazloom, Sara Khodayar, Gholamreza Bayat

引用次数: 0

摘要

丙戊酸（VA）是一种广谱抗惊厥剂，可通过多种分子机制控制不同类型的癫痫发作。该药物的主要问题是其肝毒性...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A trend over time study of hepatic Farnesoid-X-activated receptor and its downstream targets modulation by valproic acid in mice

Valproic acid (VA) is a broad-spectrum anticonvulsant agent that acts through several molecular mechanisms to control different types of seizures. The main concern of the drug is its liver toxicity...

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Toxicology Mechanisms and Methods 医学-毒理学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.