Sox9：骨肉瘤中癌症干细胞的潜在调节因子

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2024-07-05 DOI:10.1515/med-2024-0995

Xiucheng Li, Zuo Lv, Ping Zhou, SongOu Zhang, Chao Jiang

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引用次数: 0

摘要

骨肉瘤是一种侵袭性很强的骨肿瘤，主要影响儿童和青少年。尽管治疗方法不断进步，但骨肉瘤患者的预后仍然很差，因此需要对其潜在机制有更深入的了解。近年来，癌症干细胞（CSCs）的概念逐渐成为肿瘤发生、发展和耐药性的关键因素。这些特化的亚群细胞具有自我更新能力和致瘤潜能，并导致肿瘤的异质性。Sox9是一种转录因子，因其在胚胎发育和组织稳态中的关键作用而闻名，它与包括骨肉瘤在内的多种恶性肿瘤都有牵连。本综述旨在总结目前有关 Sox9 在骨肉瘤 CSCs 中的作用及其作为预后和治疗靶点的潜在意义的知识。

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Sox9: A potential regulator of cancer stem cells in osteosarcoma

Osteosarcoma is a highly aggressive bone tumor primarily affecting children and adolescents. Despite advancements in treatment modalities, the prognosis for osteosarcoma patients remains poor, emphasizing the need for a deeper understanding of its underlying mechanisms. In recent years, the concept of cancer stem cells (CSCs) has emerged as a crucial factor in tumor initiation, progression, and therapy resistance. These specialized subpopulations of cells possess self-renewal capacity, tumorigenic potential, and contribute to tumor heterogeneity. Sox9, a transcription factor known for its critical role in embryonic development and tissue homeostasis, has been implicated in various malignancies, including osteosarcoma. This review aims to summarize the current knowledge regarding the role of Sox9 in CSCs in osteosarcoma and its potential implications as a prognosis and therapeutic target.

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.