色素化学修饰的现代方法和色素库选择原则

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2024-06-04 DOI:10.3103/S002713142470010X

M. F. Subach, M. G. Khrenova, M. I. Zvereva

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引用次数: 0

摘要

摘要短链肽具有选择性配体的独特性质，可通过人工进化和组合化学方法特异性地获得或选定目标，因此有望在生物医学和各种诊断系统中广泛应用。本文讨论了在体外获得适配体和利用其化学修饰的策略，以及基于硅预测构的初始化合物库设计方法。提出了局限性，并提出了获取新的适配体领域的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Modern Methods of Aptamer Chemical Modification and Principles of Aptamer Library Selection

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Modern Methods of Aptamer Chemical Modification and Principles of Aptamer Library Selection

Aptamers are promising for a wide application range in biomedicine and various diagnostic systems due to their unique properties as selective ligands specifically obtained or a selected target using methods of artificial evolution and combinatorial chemistry. Strategies for obtaining aptamers in vitro and using their chemical modifications, as well as approaches to design the initial libraries of compounds based on in silico prestructuring are discussed. Limitations are formulated, and a direction for the development of the field of obtaining new aptamers is proposed.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.