便携式等离子发生器在感染性伤口愈合中的活体应用

IF 2.9 3区物理与天体物理 Q2 PHYSICS, APPLIED

Plasma Processes and Polymers Pub Date : 2024-07-05 DOI:10.1002/ppap.202400071

Mingze Dang, Yiqian Li, Lanlan Nie, Feng Zhao, Shaohui Jin, Xi Chen, Xinpei Lu, Lu Gan

{"title":"便携式等离子发生器在感染性伤口愈合中的活体应用","authors":"Mingze Dang, Yiqian Li, Lanlan Nie, Feng Zhao, Shaohui Jin, Xi Chen, Xinpei Lu, Lu Gan","doi":"10.1002/ppap.202400071","DOIUrl":null,"url":null,"abstract":"In this study, a portable plasma generator produced large‐area air plasma for treating infected wounds in BALB/c mice. Different plasma treatment times (30 s, 1 min, 3 min, and 4.5 min) were applied daily until the wounds healed completely. Results showed reduced inflammation and increased vascular endothelial growth factor (VEGF) expression in tissues treated for 1 and 3 min, promoting blood vessel proliferation and collagen fiber synthesis. However, treatment for 30 s and 4.5 min worsened inflammation and decreased VEGF expression. Overall, a 1‐min treatment was the most effective in promoting wound healing. Cold plasma shows promise for healing infected wounds, with treatment duration being a crucial factor.","PeriodicalId":20135,"journal":{"name":"Plasma Processes and Polymers","volume":"13 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Vivo application of a portable plasma generator in infected wound healing\",\"authors\":\"Mingze Dang, Yiqian Li, Lanlan Nie, Feng Zhao, Shaohui Jin, Xi Chen, Xinpei Lu, Lu Gan\",\"doi\":\"10.1002/ppap.202400071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, a portable plasma generator produced large‐area air plasma for treating infected wounds in BALB/c mice. Different plasma treatment times (30 s, 1 min, 3 min, and 4.5 min) were applied daily until the wounds healed completely. Results showed reduced inflammation and increased vascular endothelial growth factor (VEGF) expression in tissues treated for 1 and 3 min, promoting blood vessel proliferation and collagen fiber synthesis. However, treatment for 30 s and 4.5 min worsened inflammation and decreased VEGF expression. Overall, a 1‐min treatment was the most effective in promoting wound healing. Cold plasma shows promise for healing infected wounds, with treatment duration being a crucial factor.\",\"PeriodicalId\":20135,\"journal\":{\"name\":\"Plasma Processes and Polymers\",\"volume\":\"13 1\",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasma Processes and Polymers\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1002/ppap.202400071\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSICS, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasma Processes and Polymers","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1002/ppap.202400071","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSICS, APPLIED","Score":null,"Total":0}

引用次数: 0

摘要

在这项研究中，便携式等离子体发生器产生了大面积空气等离子体，用于治疗 BALB/c 小鼠感染的伤口。每天使用不同的血浆处理时间（30 秒、1 分钟、3 分钟和 4.5 分钟），直到伤口完全愈合。结果显示，处理 1 分钟和 3 分钟的组织炎症减轻，血管内皮生长因子（VEGF）表达增加，促进了血管增殖和胶原纤维合成。然而，30 秒和 4.5 分钟的处理会加重炎症，降低血管内皮生长因子的表达。总之，1 分钟的处理对促进伤口愈合最有效。冷等离子有望治愈感染伤口，但治疗时间长短是关键因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Vivo application of a portable plasma generator in infected wound healing

In this study, a portable plasma generator produced large‐area air plasma for treating infected wounds in BALB/c mice. Different plasma treatment times (30 s, 1 min, 3 min, and 4.5 min) were applied daily until the wounds healed completely. Results showed reduced inflammation and increased vascular endothelial growth factor (VEGF) expression in tissues treated for 1 and 3 min, promoting blood vessel proliferation and collagen fiber synthesis. However, treatment for 30 s and 4.5 min worsened inflammation and decreased VEGF expression. Overall, a 1‐min treatment was the most effective in promoting wound healing. Cold plasma shows promise for healing infected wounds, with treatment duration being a crucial factor.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Plasma Processes and Polymers 物理-高分子科学

CiteScore

6.60

自引率

11.40%

发文量

150

审稿时长

3 months

期刊介绍： Plasma Processes & Polymers focuses on the interdisciplinary field of low temperature plasma science, covering both experimental and theoretical aspects of fundamental and applied research in materials science, physics, chemistry and engineering in the area of plasma sources and plasma-based treatments.