Zhan-Peng Yu , Yu-Xia Wang , Li-Hong Hong , Ya-Lin Li , Jian-Fei Zhang , Mu Li , Ping Ying , Qiang Zheng , Ling-Yi Kong , Jian-Guang Luo
{"title":"从盐肤木种子中提取的二聚哌啶喹啉生物碱","authors":"Zhan-Peng Yu , Yu-Xia Wang , Li-Hong Hong , Ya-Lin Li , Jian-Fei Zhang , Mu Li , Ping Ying , Qiang Zheng , Ling-Yi Kong , Jian-Guang Luo","doi":"10.1016/j.phytol.2024.07.001","DOIUrl":null,"url":null,"abstract":"<div><p>A chemical investigation of extracts from the seeds of <em>Chimonanthus salicifolius</em> has led to the isolation of four new dimeric piperidinoquinoline alkaloids (<strong>1</strong>-<strong>4</strong>) and one new dimeric tryptamine alkaloid (<strong>5</strong>), along with five known alkaloids (<strong>6</strong>-<strong>10</strong>). Notably, compounds <strong>3</strong> and <strong>4</strong> were identified as two unusual dimeric piperidinoquinoline alkaloid-fatty acid hybrids. The new structures were elucidated using HRESIMS, NMR, and ECD spectroscopic techniques. The isolated compounds were subjected to cytotoxicity testing against HCT-116, HT-1080, and A549 cell lines. Compound <strong>5</strong> exhibited moderate activity against the HCT-116 and HT-1080 cell lines, with IC<sub>50</sub> values of 44.59 ± 2.08 <em>μ</em>M and 37.39 ± 2.31 <em>μ</em>M, respectively.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"62 ","pages":"Pages 38-43"},"PeriodicalIF":1.3000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dimeric piperidinoquinoline alkaloids from the seeds of Chimonanthus salicifolius\",\"authors\":\"Zhan-Peng Yu , Yu-Xia Wang , Li-Hong Hong , Ya-Lin Li , Jian-Fei Zhang , Mu Li , Ping Ying , Qiang Zheng , Ling-Yi Kong , Jian-Guang Luo\",\"doi\":\"10.1016/j.phytol.2024.07.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A chemical investigation of extracts from the seeds of <em>Chimonanthus salicifolius</em> has led to the isolation of four new dimeric piperidinoquinoline alkaloids (<strong>1</strong>-<strong>4</strong>) and one new dimeric tryptamine alkaloid (<strong>5</strong>), along with five known alkaloids (<strong>6</strong>-<strong>10</strong>). Notably, compounds <strong>3</strong> and <strong>4</strong> were identified as two unusual dimeric piperidinoquinoline alkaloid-fatty acid hybrids. The new structures were elucidated using HRESIMS, NMR, and ECD spectroscopic techniques. The isolated compounds were subjected to cytotoxicity testing against HCT-116, HT-1080, and A549 cell lines. Compound <strong>5</strong> exhibited moderate activity against the HCT-116 and HT-1080 cell lines, with IC<sub>50</sub> values of 44.59 ± 2.08 <em>μ</em>M and 37.39 ± 2.31 <em>μ</em>M, respectively.</p></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"62 \",\"pages\":\"Pages 38-43\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390024000995\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024000995","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Dimeric piperidinoquinoline alkaloids from the seeds of Chimonanthus salicifolius
A chemical investigation of extracts from the seeds of Chimonanthus salicifolius has led to the isolation of four new dimeric piperidinoquinoline alkaloids (1-4) and one new dimeric tryptamine alkaloid (5), along with five known alkaloids (6-10). Notably, compounds 3 and 4 were identified as two unusual dimeric piperidinoquinoline alkaloid-fatty acid hybrids. The new structures were elucidated using HRESIMS, NMR, and ECD spectroscopic techniques. The isolated compounds were subjected to cytotoxicity testing against HCT-116, HT-1080, and A549 cell lines. Compound 5 exhibited moderate activity against the HCT-116 and HT-1080 cell lines, with IC50 values of 44.59 ± 2.08 μM and 37.39 ± 2.31 μM, respectively.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
