心脏淀粉样变性的核成像技术。

IF 2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Current Opinion in Cardiology Pub Date : 2024-09-01 Epub Date: 2024-07-05 DOI:10.1097/HCO.0000000000001167
Jean Michel Saad, Mouaz H Al-Mallah
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引用次数: 0

摘要

综述的目的:心脏淀粉样变性是一种前体蛋白错误折叠成不溶性淀粉样纤维的疾病,会导致局限性心肌病和心力衰竭症状。这篇综述讨论了核成像技术的进展,这些技术可提高心脏淀粉样变性的诊断和指导管理,满足临床实践中早期准确检测的迫切需要:最近的研究和指南强调了核成像技术在诊断心脏淀粉样变性中的关键作用。使用99m锝-PYP、99m锝-DPD和99m锝-HMDP等骨惰性示踪剂的心脏闪烁成像有助于区分转甲状腺素淀粉样变性和轻链淀粉样变性。使用11C-匹兹堡化合物B(11C-PiB)和18F-氟贝他匹等示踪剂的正电子发射计算机断层显像(PET)在测量淀粉样蛋白负荷和监测疾病进展方面具有巨大潜力,可提供有关心肌受累情况的详细资料。这些方法可提供更准确的诊断、对疾病程度的详细评估以及对淀粉样变性类型的更好区分,这对定制治疗方法至关重要。将这些技术融入临床实践对于改善患者预后和推进心脏淀粉样变性研究至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nuclear imaging techniques for cardiac amyloidosis.

Purpose of review: Cardiac amyloidosis is a condition marked by the misfolding of precursor proteins into insoluble amyloid fibrils, leading to restrictive cardiomyopathy and heart failure symptoms. This review discusses advancements in nuclear imaging techniques that enhance the diagnosis and guide the management of cardiac amyloidosis, addressing the critical need for early and accurate detection in clinical practice.

Recent findings: Recent studies and guidelines emphasizes the pivotal role of nuclear imaging techniques in diagnosing cardiac amyloidosis. Cardiac scintigraphy, using bone-avid tracers like 99mTc-PYP, 99mTc-DPD, and 99mTc-HMDP, is instrumental in distinguishing between transthyretin amyloidosis and light chain amyloidosis. PET, with tracers such as 11C-Pittsburgh Compound B (11C-PiB) and 18F-Florbetapir, offers significant potential in measuring amyloid burden and monitoring disease progression, providing detailed insights into the myocardial involvement.

Summary: The advancements in nuclear imaging techniques significantly impact the management of cardiac amyloidosis. These methods allow for a more accurate diagnosis, detailed assessment of disease extent, and better differentiation between amyloidosis types, which are crucial for tailoring treatment approaches. The integration of these techniques into clinical practice is essential for improving patient outcomes and advancing research in cardiac amyloidosis.

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来源期刊
Current Opinion in Cardiology
Current Opinion in Cardiology 医学-心血管系统
CiteScore
4.20
自引率
4.30%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Cardiology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With fourteen disciplines published across the year – including arrhythmias, molecular genetics, HDL cholesterol and clinical trials – every issue also contains annotated reference detailing the merits of the most important papers.
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