评估输注含有 HLA I 类抗体的血液成分后患者的输血反应 - 预防患者 TRALI 的尝试。

IF 1.4 4区医学 Q4 HEMATOLOGY

Transfusion and Apheresis Science Pub Date : 2024-07-02 DOI:10.1016/j.transci.2024.103970

Nhan T. Nguyen, Thomas Larsen Titze, Lise Sofie H. Nissen-Meyer

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引用次数: 0

摘要

为了减轻输血相关急性肺损伤（TRALI），奥斯陆血液中心对 1369 名血栓形成捐献者进行了人类白细胞抗原（HLA）特异性抗体筛查。在 200 名被推迟捐献富血浆产品的捐献者中发现了抗 HLA 抗体。在一项回顾性研究中，对其中 150 名捐献者的 2562 次血小板输注（包括无细胞血浆和全血）进行了彻底的回顾调查。共发现 14 例输血反应报告，其中没有一例被归类为 TRALI。我们的研究支持之前的数据，表明 TRALI 的风险很低。对抗 HLA 抗体进行筛查并随后推迟高水平抗 HLA 抗体捐献者的价值仍然值得怀疑。

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Evaluation of transfusion reactions in patients following transfusion of blood components containing antibodies to HLA class I – An attempt to prevent TRALI in patients

In an attempt to mitigate transfusion-related acute lung injury (TRALI), the Oslo Blood Center screened 1369 thrombapheresis donors for human leucocyte antigen (HLA)-specific antibodies. Anti-HLA antibodies were found in 200 donors who were deferred from donation of plasma-rich products. In a retrospective study, 2562 transfusions of thrombocytes (both apheresis and whole blood-derived) from 150 of these donors were subject to a thorough look back-investigation. Reports of 14 transfusion reactions were identified, none of which were classified as TRALI. Our study supports previous data indicating that the risk of TRALI is low. The value of screening for anti-HLA antibodies and subsequent deferral of donors with high levels of such antibodies remains questionable.

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来源期刊

Transfusion and Apheresis Science 医学-血液学

CiteScore

3.60

自引率

5.30%

发文量

181

审稿时长

42 days

期刊介绍： Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues. Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.