Emin Uysal, Sabiha Gulce Yavas, Gokce Dicle Kalaycioglu, Mustafa Polat, Halil Kalipcilar, Nihal Aydogan
{"title":"刺激响应型纳米平台:基于二茂铁表面活性剂的ZIF-8蜕变囊泡的协同治疗应用","authors":"Emin Uysal, Sabiha Gulce Yavas, Gokce Dicle Kalaycioglu, Mustafa Polat, Halil Kalipcilar, Nihal Aydogan","doi":"10.1002/admi.202400169","DOIUrl":null,"url":null,"abstract":"<p>One of the most important issues in the design and preparation of drug delivery systems in the recent years is versatility which includes providing synergistic therapeutic effects and sustainability. This study uses a redox-active ferrocenyl surfactant (FcN<sup>+</sup>(CH<sub>2</sub>CH<sub>3</sub>)<sub>3</sub>(CH<sub>2</sub>)<sub>10</sub>CH<sub>3</sub>, Fc(C<sub>11</sub>) where Fc is ferrocene) and pH responsive Zeolitic Imidazolate Framework-8 (ZIF-8) structures to form multifunctional assemblies (Fc(C<sub>11</sub>)-AOT/Rhb@ZIF-8/PDA) that can be used in several application including the drug delivery. The vesicles prepared using AOT-FC(C<sub>11</sub>) constitute the core of the structure. Since the location of the ferrocene group in the molecule structure, which is next to head group, the surface of the vesicles is decorated with the ferrocene group which can act as a Fenton reaction catalyst. The polydopamine (PDA) covered ZIF-8 are used to decorate the surface of the vesicles, creating a truly remarkable structure. The porous structure of ZIF-8 as well as the core of the vesicles can accommodate drug molecules. With the added NIR-responsive character upon PDA coating, this assembled structure can be used for phototermal therapy applications. The properties of this designed multifunctional and multi-responsive system are studied at different pH and under NIR-laser irradiation and show that it has potential to display a triple chemodynamic/ photothermal/ chemotherapeutic effect.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202400169","citationCount":"0","resultStr":"{\"title\":\"Stimuli-Responsive Nanoplatforms: ZIF-8-Decorated Ferrocenyl Surfactant-Based Vesicles for Synergistic Therapeutic Applications\",\"authors\":\"Emin Uysal, Sabiha Gulce Yavas, Gokce Dicle Kalaycioglu, Mustafa Polat, Halil Kalipcilar, Nihal Aydogan\",\"doi\":\"10.1002/admi.202400169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>One of the most important issues in the design and preparation of drug delivery systems in the recent years is versatility which includes providing synergistic therapeutic effects and sustainability. 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Stimuli-Responsive Nanoplatforms: ZIF-8-Decorated Ferrocenyl Surfactant-Based Vesicles for Synergistic Therapeutic Applications
One of the most important issues in the design and preparation of drug delivery systems in the recent years is versatility which includes providing synergistic therapeutic effects and sustainability. This study uses a redox-active ferrocenyl surfactant (FcN+(CH2CH3)3(CH2)10CH3, Fc(C11) where Fc is ferrocene) and pH responsive Zeolitic Imidazolate Framework-8 (ZIF-8) structures to form multifunctional assemblies (Fc(C11)-AOT/Rhb@ZIF-8/PDA) that can be used in several application including the drug delivery. The vesicles prepared using AOT-FC(C11) constitute the core of the structure. Since the location of the ferrocene group in the molecule structure, which is next to head group, the surface of the vesicles is decorated with the ferrocene group which can act as a Fenton reaction catalyst. The polydopamine (PDA) covered ZIF-8 are used to decorate the surface of the vesicles, creating a truly remarkable structure. The porous structure of ZIF-8 as well as the core of the vesicles can accommodate drug molecules. With the added NIR-responsive character upon PDA coating, this assembled structure can be used for phototermal therapy applications. The properties of this designed multifunctional and multi-responsive system are studied at different pH and under NIR-laser irradiation and show that it has potential to display a triple chemodynamic/ photothermal/ chemotherapeutic effect.
期刊介绍:
Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018.
The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface.
Advanced Materials Interfaces covers all topics in interface-related research:
Oil / water separation,
Applications of nanostructured materials,
2D materials and heterostructures,
Surfaces and interfaces in organic electronic devices,
Catalysis and membranes,
Self-assembly and nanopatterned surfaces,
Composite and coating materials,
Biointerfaces for technical and medical applications.
Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.