基于酒精的电促进帕塞里尼式反应

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2024-06-12 DOI:10.1055/a-2333-8596

Alexandre Simon, Sylvestre P. J. T. Bachollet, Na Pan, Laurence Grimaud, Maxime R. Vitale

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引用次数: 0

摘要

本文报告了一种基于酒精的帕塞里尼氧化反应的电化学变体。该反应依赖于间接阳极氧化过程，然后进行三组分耦合，其中 TEMPO 是关键的氧化还原介质。这种电化学方法无需金属催化剂，也不需要氧气环境，可以使用非活化醇作为反应伙伴。该方法可用于制备多种α-乙酰氧基羧酰胺，产率在 24% 至 80% 之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electromediated Alcohol-Based Passerini-Type Reaction

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Electromediated Alcohol-Based Passerini-Type Reaction

An electrochemical variant of the alcohol-based oxidative Passerini reaction is reported here. It relies on an indirect anodic oxidation process followed by a three-component coupling, in which TEMPO serves as a key redox mediator. This electrochemical approach permits to operate without the need for a metal catalyst nor oxygen atmosphere and allows the use of nonactivated alcohols as reaction partners. It could be applied to the preparation of good variety of α-acyloxy-carboxamides in yields ranging from 24% to 80%.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.