222b - 人类生物监测的相关信息和挑战
IF 1.8
4区 医学
Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
引用次数: 0
摘要
人体生物监测（HBM）已被证明是进行化学品风险评估的有用工具。不过，可靠的 HBM 还需要考虑某些标准。必须了解所选生物基质的适用性以及生物标志物的特异性和敏感性。对于特定的 HBM 来说，生物标志物必须不是由其他预期暴露的物质形成的。生物标志物的灵敏度取决于研究的目的，与验证是否符合基于健康的指导值（例如，在职业环境中）相比，调查普通人群的本底暴露需要更高的灵敏度。此外，还需要考虑生物标记分析的耐用性，如分析前污染的易感性。为了获得有效的 HBM 结果，这些生物标记物的分析方法必须具有足够的灵敏度、选择性和耐用性，并且必须在有质量保证的条件下应用。本讲座将通过实际案例讨论如何选择可靠的生物标记物。本文章由计算机程序翻译，如有差异，请以英文原文为准。
222b - Relevant information and challenges for human biomonitoring
Human biomonitoring (HBM) has proven to be a useful tool to perform risk assessment of chemicals. Nevertheless, certain criteria for a reliable HBM should be taken into account. Knowledge regarding the suitability of the chosen biological matrix, as well as the specificity and sensitivity of biomarkers is essential. For a specific HBM, the biomarker must not be formed from other substances with expected exposures. The sensitivity of the biomarker depends on the aim of the study with higher sensitivities needed for the investigation of background exposures in the general population, compared to verifying the adherence to health-based guidance values (e.g., in an occupational context). Furthermore, aspects of analytical ruggedness of the biomarkers need to be considered, such as susceptibility to pre-analytical contamination. To obtain valid HBM results, analytical methods for these biomarkers need to be sufficiently sensitive, selective, and rugged and need to be applied under quality-assured conditions. In this presentation, the choice of a reliable biomarker will be discussed using practical examples.
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来源期刊
Annals Of Work Exposures and Health
Medicine-Public Health, Environmental and Occupational Health
CiteScore
4.60
自引率
19.20%
发文量
79
期刊介绍：
About the Journal
Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?"
We are interested in high quality scientific research addressing:
the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures;
the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities;
populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers;
the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems;
policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities;
methodologies and mechanisms that underlie the quantification and/or control of exposure and risk.
There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.
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