在碳酸钾存在下通过 5-苄基梅尔德鲁酸与 TosMIC 的串联反应合成 1,3-氧氮杂卓衍生物

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-06-19 DOI:10.1002/jhet.4860

Furgan Aslanoglu

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引用次数: 0

摘要

我们开发出了一种合成 1,3-氧氮杂卓的高效新方法。该方法的合成策略首先是通过 Knoevenagel 反应生成 5-苄啶-梅尔德鲁姆酸，然后在碱存在下与 TosMIC（对甲苯磺酸甲基异氰酸酯）进行 7-内向环化反应。在对这一串联反应进行的优化研究中，使用 K2CO3 作为碱时，产率最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of 1,3-oxazepine derivatives via tandem reaction of 5-benzylidine Meldrum's acids with TosMIC in presence of potassium carbonate

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Synthesis of 1,3-oxazepine derivatives via tandem reaction of 5-benzylidine Meldrum's acids with TosMIC in presence of potassium carbonate

A new and efficient method for synthesizing 1,3-oxazepines has been developed. The synthetic strategy of this method is based initially on the Knoevenagel reaction to form 5-benzylidine Meldrum's acid, followed by a 7-endo-cyclization reaction with TosMIC (p-toluenesulfonylmethyl isocyanide) in the presence of base. In the optimization studies carried out on this tandem reaction, the highest yield was obtained when K₂CO₃ was used as the base.

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.