三唑并嘧啶的合成进展

IF 1.7 3区化学 Q3 CHEMISTRY, ORGANIC

Current Organic Chemistry Pub Date : 2024-06-26 DOI:10.2174/0113852728313437240607095009

Sushma Singh, Raman Lakhia, Sidhant Yadav, Poonam Devi, Karmvati Yadav, Vishwas Chaudhri, Rashmi Pundeer

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引用次数: 0

摘要

:三唑并嘧啶支架因其多变的药理特性而在药物化学中占有重要地位。研究人员已经探索了该支架及其衍生物在各种治疗中的应用。三唑并嘧啶的独特结构使其成为设计药用活性分子的宝贵模板。大量文献研究展示了含有三唑并嘧啶环（与其他杂环融合或偶联）的化合物的合成和生物活性。本综述旨在对三唑并嘧啶衍生物合成方面的最新进展（2021 年至今）进行全面而概括的总结。

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Advancements in the Synthesis of Triazolopyrimidines

: The triazolopyrimidine scaffold indeed holds a prominent place in medicinal chemistry due to its versatile pharmacological properties. Researchers have explored the scaffold and its derivatives for various therapeutic applications. The unique structure of triazolopyrimidine has made it a valuable template for designing medicinally active molecules. The literature is full of studies showcasing the synthesis and biological activities of compounds containing the triazolopyrimidine ring, either fused or coupled with other heterocycles. The aim of this review is to provide a comprehensive and general summary of the recent advancements in the synthesis of triazolopyrimidine derivatives (Year 2021 to present).

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来源期刊

Current Organic Chemistry 化学-有机化学

CiteScore

3.70

自引率

7.70%

发文量

审稿时长

1 months

期刊介绍： Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.