G. Z. Raskil’dina, Yu. G. Borisova, A. N. Vereshchagin, E. V. Detusheva, R. M. Sultanova, S. S. Zlotskii
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Biological Activity of Quaternary Ammonium Salts Containing 1,3-Dioxolane or gem-Dichlorocyclopropane Fragment
Abstract
Quaternary ammonium salts (QASs) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane fragments were prepared in 40–90% yields based on pyridine, hexamethylenetetramine, and tertiary amines. The structures of the obtained salts were identified by 1H and 13C NMR spectroscopy. The antibacterial activity of QAS against a bacterial strain (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinobacter Baumanii) were assessed. Among the salts tudied, leader compounds were identified that exhibited high antibacterial activity.
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