[用减量全反式维甲酸成功诱导并发 COVID-19 的急性早幼粒细胞白血病患者缓解病情]。

Rintaro Fujimoto, Tsuyoshi Kamae, Kimimori Kamijo, Masato Yasumi, Takahiro Karasuno
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引用次数: 0

摘要

一名全血细胞减少的 43 岁男子被诊断为急性早幼粒细胞白血病(APL)。在单用全反式维甲酸(ATRA)进行诱导治疗的第一天,他出现了高烧,并通过 SARS-CoV2 抗原检测发现感染了冠状病毒病 2019(COVID-19)。一般建议对感染 COVID-19 的 APL 患者推迟治疗,除非需要紧急治疗 APL,但该患者因 APL 引起弥散性血管内凝血(DIC)而需要继续治疗。考虑到区分分化综合征(DS)和 COVID-19 恶化的难度,ATRA 的剂量被减至 50%。患者能够继续接受治疗,没有出现分化综合征或 DIC 恶化,从而摆脱了 COVID-19 并缓解了 APL。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Successful remission induction with reduced-dose all-trans retinoic acid for acute promyelocytic leukemia complicated by COVID-19].

A 43-year-old man with pancytopenia was diagnosed with acute promyelocytic leukemia (APL). On the first day of induction therapy with all-trans retinoic acid (ATRA) alone, he presented with high fever and was found to have coronavirus disease 2019 (COVID-19) infection by SARS-CoV2 antigen test. While it is generally recommended to delay treatment for APL patients with COVID-19 unless urgent APL treatment is required, this patient needed to continue treatment due to APL-induced disseminated intravascular coagulation (DIC). Considering the challenge of distinguishing between differentiation syndrome (DS) and COVID-19 exacerbation, the ATRA dosage was reduced to 50%. The patient was able to continue treatment without development of DS or exacerbation of DIC, leading to his recovery from COVID-19 and remission of APL.

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