分泌过程中 COPII 蛋白的定制组装。

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2024-08-05 Epub Date: 2024-07-03 DOI:10.1083/jcb.202404013

Vivek Malhotra

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引用次数: 0

摘要

从内质网（ER）导出分泌货物需要 COPII 蛋白，人们最初发现 COPII 蛋白能够包裹从 ER 萌发的小囊泡。最近的数据表明，COPII 蛋白还能在小管的颈部组织成环，以及相分离成液体状凝聚体。因此，COPII 的组装似乎是量身定制的，以适应分泌货物的大小和数量的变化。

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Tailored assemblies of COPII proteins in secretion.

Export of secretory cargoes from the endoplasmic reticulum (ER) requires COPII proteins, which were first identified for their ability to coat small vesicles that bud from the ER. Recent data indicate that COPII proteins can also organize into a collar at the necks of tubules, as well as phase-separate into liquid-like condensates. Thus, COPII assemblies seem to be tailored to accommodate variations in the size and quantities of cargo secreted.

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.