Zhuo-Hang Zhang, Bo Wang, Yan Peng, Ya-Wei Xu, Chang-Hong Li, Ya-Lei Ning, Yan Zhao, Fa-Bo Shan, Bo Zhang, Nan Yang, Jing Zhang, Xing Chen, Ren-Ping Xiong, Yuan-Guo Zhou, Ping Li
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引用次数: 0
摘要
运动学习(ML)在生长和身体康复中起着基础性作用,它涉及通过不同脑区进行的不同阶段的学习和记忆过程。然而,人们对运动学习的神经机制还不够了解。在这里,研究人员发现了一种以前未报道过的从海马背侧(dHPC)到内侧带(ZI)的神经元投射,它参与了对ML行为的调控。通过使用重组腺相关病毒,令人惊奇地发现通向 ZI 的投射源自 dHPC 的背侧齿状回(DG)和 CA1 亚区。此外,投射特异性化学遗传学和光遗传学操作显示,从背侧 CA1 到 ZI 的投射在 ML 行为的获得和巩固中起关键作用,而从背侧 DG 到 ZI 的投射则介导 ML 行为的检索/保留。研究结果揭示了从背侧DG和背侧CA1到ZI的新投射参与了对ML的调控,并深入揭示了这种调控发生的阶段。
Identification of a Hippocampus-to-Zona Incerta Projection involved in Motor Learning
Motor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions. However, the neural mechanisms that underlie ML are not sufficiently understood. Here, a previously unreported neuronal projection from the dorsal hippocampus (dHPC) to the zona incerta (ZI) involved in the regulation of ML behaviors is identified. Using recombinant adeno-associated virus, the projections to the ZI are surprisingly identified as originating from the dorsal dentate gyrus (DG) and CA1 subregions of the dHPC. Furthermore, projection-specific chemogenetic and optogenetic manipulation reveals that the projections from the dorsal CA1 to the ZI play key roles in the acquisition and consolidation of ML behaviors, whereas the projections from the dorsal DG to the ZI mediate the retrieval/retention of ML behaviors. The results reveal new projections from the dorsal DG and dorsal CA1 to the ZI involved in the regulation of ML and provide insight into the stages over which this regulation occurs.
期刊介绍:
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.