膳食镁摄入量与 2 型糖尿病患者和非 2 型糖尿病患者的动脉粥样硬化性心血管疾病风险和死亡率的关系：英国生物库的一项前瞻性研究。

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & metabolism Pub Date : 2024-06-29 DOI:10.1016/j.diabet.2024.101554

Ruyu Huang , Xinxin Kong , Rui Geng , Jingwei Wu , Jiong Li , Yong Gu , Yaqian Wu , Dongfang You , Yang Zhao , Senmiao Ni , Zihang Zhong , Jianling Bai

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引用次数: 0

摘要

背景：- 膳食镁（Mg）摄入量与动脉粥样硬化性心血管疾病（ASCVD）风险之间的关系仍不确定。我们旨在研究膳食镁摄入量与2型糖尿病患者和非2型糖尿病患者的ASCVD事件和死亡风险之间的关系。采用 Cox 比例危险模型估算了危险比（HRs）和 95%CIs 。此外，还研究了膳食镁摄入量与 2 型糖尿病状态在乘法和加法上的交互作用：- 在12.0年和12.1年的中位随访期间，分别记录了7811例ASCVD事件和5000例死亡（包括599例ASCVD死亡）。充足的膳食镁摄入量（等于或高于每日推荐摄入量）与 ASCVD 发病风险（HR 0.63 [95%CI 0.49;0.82]）、ASCVD 死亡率（HR 0.45 [0.24;0.87]）和全因死亡率（HR 0.71[0.52;0.97]），而在未患 2 型糖尿病的参与者中未观察到显著关联（ASCVD 发病率 HR 1.01 [0.94;1.09]; ASCVD 死亡率 HR 1.25 [0.93;1.66]; 全因死亡率 HR 0.97 [0.88;1.07]）。结论：-充足的膳食镁摄入量与降低2型糖尿病患者的ASCVD事件和死亡风险有显著相关性，但与非2型糖尿病患者无关。我们的研究结果使人们深入了解了膳食中镁的摄入量对降低2型糖尿病患者可改变的心血管负担的重要性，这可能为未来的个性化膳食指南提供参考。

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Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank

Background

The association between dietary magnesium (Mg) intake and the risk of atherosclerotic cardiovascular disease (ASCVD) remains uncertain. We aimed to examine the associations of dietary Mg intake with the risk of ASCVD events and mortality in individuals with and without type 2 diabetes.

Methods

A total of 149,929 participants (4603 with type 2 diabetes) from the UK Biobank were included in the analyses. The hazard ratios (HRs) and 95 % confidence intervals (CIs) were estimated using Cox proportional hazard models. Furthermore, interactions of dietary Mg intake with type 2 diabetes status were examined on multiplicative and additive scales.

Results

During a median follow-up of 12.0 and 12.1 years, 7811 incident ASCVD events and 5000 deaths (including 599 ASCVD deaths) were documented, respectively. There were significantly negative associations between sufficient dietary Mg intake (equal to or greater than the recommended daily intake) and the risk of ASCVD incidence (HR 0.63 [95 % CI 0.49;0.82]), ASCVD mortality (0.45 [0.24;0.87]), and all-cause mortality (0.71 [0.52;0.97]) in participants with type 2 diabetes, whereas no significant association was observed in participants without type 2 diabetes (1.01 [0.94;1.09] for ASCVD incidence; 1.25 [0.93;1.66] for ASCVD mortality; 0.97 [0.88;1.07] for all-cause mortality). Multiplicative and additive interactions of dietary Mg intake with type 2 diabetes status were both observed.

Conclusion

Sufficient dietary Mg intake was significantly associated with lower risks of ASCVD events and mortality in individuals with type 2 diabetes but not in those without type 2 diabetes. Our findings provide insight into the importance of dietary Mg intake for reducing modifiable cardiovascular burden in individuals with type 2 diabetes, which may inform future personalized dietary guidelines.

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来源期刊

Diabetes & metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.20%

发文量

审稿时长

13 days

期刊介绍： A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.