1993-2022 年斯洛伐克的侵袭性和转移性水瘤。

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Liam McCullough, Ludovit Danihel, Jozef Sufliarsky, Michaela Kubickova, Zuzana Niznanska, Adam Adamec, Miroslav Korbel
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引用次数: 0

摘要

目的:对斯洛伐克共和国(SR)的侵袭性和转移性水瘤(HM)--流行病学、患者特征和治疗效果进行回顾性分析:对斯洛伐克共和国(SR)的浸润性和转移性水滴状痣(HM)--流行病学、患者特征和治疗结果--进行回顾性分析:背景:浸润性和转移性水瘤是一种高度可治愈的妊娠滋养细胞肿瘤。浸润性和转移性痣均可通过子宫切除术治愈,无需辅助化疗:方法:1993 年至 2022 年期间,19 例经组织病理学证实的 HM(10 例浸润性和 9 例转移性)在 SR 接受了治疗。根据治疗方式将患者分为两组(仅子宫切除术--8 例;子宫切除术和化疗--11 例)。分析参数包括患者年龄、先兆妊娠、人绒毛膜促性腺激素水平、肿瘤大小和缓解时间:SR中浸润性和转移性HM的发病率为1:121,253,即1:86,589。总体治愈率为 100%,无复发。有 14 名患者接受了子宫切除术作为一线治疗,治愈率为 57.1%。在 8 名接受一线子宫切除术的转移痣患者中,有 4 人(50%)无需化疗即可治愈。两组患者在所有选定参数上的差异均无统计学意义:结论:一线子宫切除术可使浸润性和转移性 HM 患者在不进行辅助化疗的情况下获得缓解,或减少化疗次数(表 4,图 2,参考文献 21)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Invasive and metastatic hydatidiform moles in Slovakia in 1993‒2022.

Objective: A retrospective analysis of invasive and metastatic hydatidiform moles (HM) in the Slovak Republic (SR)‒epidemiology, patient characteristics and treatment outcomes.

Backround: Invasive and metastatic mole is a highly curable type of gestational trophoblastic neoplasia. Both invasive and metastatic HM may be cured by hysterectomy without adjuvant chemotherapy.

Methods: Nineteen cases of histopathologically confirmed HM (10 invasive and 9 metastatic) were treated in SR from 1993 to 2022. Patients were divided into two groups according to treatment modality (hysterectomy only ‒ 8; hysterectomy and chemotherapy ‒ 11). The parameters included in the analysis were patient age, antecedent pregnancy, human chorionic gonadotropin level, tumor size and time to remission.

Results: The incidence of invasive and metastatic HM in the SR was 1:121,253 pregnancies, or 1:86,589 live births. The overall cure rate was 100%, without recurrence. Hysterectomy was performed as first-line therapy in 14 patients, with a cure rate of 57.1%. 4 out of 8 patients (50%) with metastatic moles, who underwent first-line hysterectomy, were cured without chemotherapy. There was no statistically significant difference between the two groups in all selected parameters.

Conclusion: First-line hysterectomy may lead to remission without adjuvant chemotherapy or reduce the number of chemotherapies in invasive and metastatic HM (Tab. 4, Fig. 2, Ref. 21).

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
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