使用含有炔雌醇-炔诺酮的避孕药可提高女性的性能力，尽管循环中的雄激素减少了：一项试验研究。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI:10.1080/13625187.2024.2369833

Maurizio Guida, Luciano Quercitelli, Pasquale De Franciscis, Mariano Fiorenza, Alice Sgandurra, Antonio La Marca, Giovanni Grandi

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引用次数: 0

摘要

目的：评估含有炔诺酮（NGM）的复合口服避孕药（COC）对女性性欲和使用者体内循环雄激素水平的初步影响：开始服用含炔雌醇（EE）35微克和炔诺酮（NGM）0.250毫克的单相避孕药的女性，在六个月内对麦考伊女性性能力问卷（MFSQ）以及睾酮（T）和硫酸脱氢表雄酮（DHEAS）血清水平进行修改：36 名受试者完成了研究。在治疗期间，MFSQ 有明显增加（p p p p 结论）：尽管雄性激素水平明显下降，但使用 EE/NGM 避孕对性欲的影响在短期内不会下降。使用化学避孕药期间的女性性能力是一个复杂的话题，不仅与血清雄激素水平的变化有关。

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The use of a pill containing ethinylestradiol-norgestimate improves female sexuality despite the decrease in circulating androgens: a pilot study.

Purpose: To evaluate the initial impact of a combined oral contraceptive (COC) containing norgestimate (NGM) on female sexuality and on circulating androgen levels in users.

Materials and methods: Six months modification in the McCoy Female Sexuality Questionnaire (MFSQ) and testosterone (T) and dehydroepiandrosterone sulphate (DHEAS) serum levels in women starting a monophasic pill containing ethinyl-estradiol (EE) 35 µg and NGM 0.250 mg.

Results: The study was completed by 36 subjects. There was a significant increase in MFSQ during treatment (p < 0.0001) (and its domains with the exclusion of vaginal lubrication domain) with concomitant decreases in T (-4.45%, p < 0.0001) and DHEAS (-19.41%, p < 0.0001) serum levels.

Conclusions: Contraception with EE/NGM was associated with a short term non-deteriorating effect on sexuality despite the evident decrease in androgen levels. Female sexuality during COC use is a complex topic and is not only linked with changes in serum androgen levels.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.