重新评估生物群变化:重塑环境对慢性免疫疾病的影响,探索新的治疗机会。

IF 2.5 3区 工程技术 Q2 BIOLOGY
Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI:10.59249/VUNF1315
William Parker, Kateřina Jirků, Esha Patel, Lauren Williamson, Lauren Anderson, Jon D Laman
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引用次数: 0

摘要

环境错配是指环境变化引发公共卫生危机。众所周知,导致慢性疾病的错配包括促进不健康饮食和久坐不动的生活方式的技术,这两种因素都会对心血管健康产生不利影响。本评论将这些错配与生物群改变联系起来,生物群改变是一种环境错配,涉及避免传染病所必需的卫生相关技术。卫生相关技术的实施会导致共生蠕虫和原生动物的丧失,从而严重影响免疫功能并引发各种慢性疾病,包括过敏性疾病、自身免疫性疾病和一些与炎症相关的神经精神疾病。遗憾的是,尽管人们对这种环境错配和其他环境错配的生物学基础已经有了一定的了解,但公共卫生机构却未能阻止由此造成的慢性疾病负担加重的趋势。生物医学研究和临床实践仍然以无效和被动的药物治疗为基础。本文认为,未来的医疗保健可以考虑当今的生物学,有效并积极地应对环境错配和由此造成的慢性疾病负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reevaluating Biota Alteration: Reframing Environmental Influences on Chronic Immune Disorders and Exploring Novel Therapeutic Opportunities.

Environmental mismatches are defined as changes in the environment that induce public health crises. Well known mismatches leading to chronic disease include the availability of technologies that facilitate unhealthy diets and sedentary lifestyles, both factors that adversely affect cardiovascular health. This commentary puts these mismatches in context with biota alteration, an environmental mismatch involving hygiene-related technologies necessary for avoidance of infectious disease. Implementation of hygiene-related technologies causes a loss of symbiotic helminths and protists, profoundly affecting immune function and facilitating a variety of chronic conditions, including allergic disorders, autoimmune diseases, and several inflammation-associated neuropsychiatric conditions. Unfortunately, despite an established understanding of the biology underpinning this and other environmental mismatches, public health agencies have failed to stem the resulting tide of increased chronic disease burden. Both biomedical research and clinical practice continue to focus on an ineffective and reactive pharmaceutical-based paradigm. It is argued that the healthcare of the future could take into account the biology of today, effectively and proactively dealing with environmental mismatch and the resulting chronic disease burden.

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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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