少克隆带

IF 2.4 Q2 CLINICAL NEUROLOGY

PRACTICAL NEUROLOGY Pub Date : 2024-09-13 DOI:10.1136/pn-2023-003814

Mark D Willis, Karim L Kreft, Bethan Dancey

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引用次数: 0

摘要

少克隆带 (OCB) 代表鞘内免疫球蛋白 G (IgG)，可通过等电聚焦和免疫固定法检测到。将脑脊液（CSF）与配对的血清样本一起分析，可得到五种不同的免疫固定模式。它们是类型 1-正常生理状态，鞘内无 IgG 合成；类型 2-有证据表明鞘内有 IgG 合成，但 CSF 限制了 OCB；类型 3-有证据表明鞘内有 IgG 合成，但 CSF 限制了 OCB，但 CSF 和血清中有额外的相同条带；类型 4-鞘内 IgG 合成缺失，但 CSF 和血清中的 OCB 相同；类型 5-鞘内 IgG 合成缺失，但 CSF 和血清中有单克隆带。对这些模式的分析有助于诊断一系列神经系统疾病，包括多发性硬化症。但是，在解释 OCB 结果时，必须结合其他 CSF 检测及其临床背景。

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Oligoclonal bands.

Oligoclonal bands (OCBs) represent the presence of intrathecal immunoglobulin G (IgG) as detected by isoelectric focusing and immunofixation. Cerebrospinal fluid (CSF) analysed alongside a paired serum sample gives five different immunofixation patterns. These are: type 1-the normal physiological state with no intrathecal IgG synthesis; type 2-evidence for intrathecal IgG synthesis, with CSF-restricted OCBs; type 3-evidence for intrathecal IgG synthesis, with CSF-restricted OCBs, but with additional, identical bands in the CSF and serum; type 4-absence of intrathecal IgG synthesis, but with identical OCBs in CSF and serum; and type 5-absence of intrathecal IgG synthesis, with a monoclonal band in CSF and serum. Analysis of these patterns can help to diagnose a range of neurological conditions, including multiple sclerosis. However, it is important to interpret OCB results alongside other CSF tests and their clinical context.

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来源期刊

PRACTICAL NEUROLOGY Medicine-Neurology (clinical)

CiteScore

3.70

自引率

3.60%

发文量

113

期刊介绍： The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.