探索药物再利用治疗抑郁症的潜力。

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Chaitenya Verma, Kritika Jain, Ashok Saini, Indra Mani, Vijai Singh
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引用次数: 0

摘要

由于成本上升和新药研发速度放缓,研究人员对现有药物的再利用或药物重新定位很感兴趣。其他授权这些治疗方法的调查使用了实验研究和标示外用药的数据。对抑郁症病因的更多研究可促使更有效的药品再定位工作。除了血清素和肾上腺素等神经递质的流失,炎症、血流量不足和神经毒素现在也被认为是合理的机制。由于存在这些其他机制,治疗耐药性抑郁症的药物也出现了用途调整。本章将重点介绍替代疗法及其在药物重新定位方面的有效性。非典型抗精神病药物、中枢神经系统兴奋剂和神经递质拮抗剂已被研究用于可能的再利用。然而,要确保这些药物的配方、有效性和合规性,还需要进行广泛的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the potential of drug repurposing for treating depression.

Researchers are interested in drug repurposing or drug repositioning of existing pharmaceuticals because of rising costs and slower rates of new medication development. Other investigations that authorized these treatments used data from experimental research and off-label drug use. More research into the causes of depression could lead to more effective pharmaceutical repurposing efforts. In addition to the loss of neurotransmitters like serotonin and adrenaline, inflammation, inadequate blood flow, and neurotoxins are now thought to be plausible mechanisms. Because of these other mechanisms, repurposing drugs has resulted for treatment-resistant depression. This chapter focuses on therapeutic alternatives and their effectiveness in drug repositioning. Atypical antipsychotics, central nervous system stimulants, and neurotransmitter antagonists have investigated for possible repurposing. Nonetheless, extensive research is required to ensure their formulation, effectiveness, and regulatory compliance.

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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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