使用双能 CT 和高场磁共振量化纳米羟基磷灰石与天然马羟基磷灰石的放射学特性。

IF 4.2 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Katarzyna Skierbiszewska DVM , Urszula Szałaj PhD Eng. , Bernard Turek DVM PhD DSc , Olena Sych PhD Eng. , Tomasz Jasiński DVM PhD , Witold Łojkowski Professor , Małgorzata Domino DVM MSc PhD DSc
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引用次数: 0

摘要

在马医学中,辅助骨再生,包括使用羟基磷灰石(HAP)等生物材料替代品,对于解决骨缺损问题至关重要。为了跟踪基于 HAP 的骨缺损治疗结果,需要推进量化诊断成像方案。本研究旨在使用磁共振 (MR) 和计算机断层扫描 (CT)(包括单能 (SECT) 和双能 (DECT))量化和比较 HAP 移植骨和天然马骨的放射学特性。SECT 和 DECT 可通过相对密度 (RD) 的逐渐增加来区分三种 HAP 晶粒大小。通过增强 HAP/水、钙/水和水/钙重建中的有效 Z 值和材料密度 (MD),同时缩短 T2 弛豫时间,SECT、DECT 和 MR 能够区分天然皮质骨和合成 HAP 移植骨。所提出的量化方法为了解 HAP 移植物的组成提供了宝贵的放射学见解,这可能对后续骨缺损治疗有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Radiological properties of nano-hydroxyapatite compared to natural equine hydroxyapatite quantified using dual-energy CT and high-field MR

Radiological properties of nano-hydroxyapatite compared to natural equine hydroxyapatite quantified using dual-energy CT and high-field MR

In equine medicine, assisted bone regeneration, including use of biomaterial substitutes like hydroxyapatite (HAP), is crucial for addressing bone defects. To follow-up on the outcome of HAP-based bone defect treatment, the advancement in quantified diagnostic imaging protocols is needed. This study aimed to quantify and compare the radiological properties of the HAP graft and natural equine bone using Magnetic Resonance (MR) and Computed Tomography (CT), both Single (SECT) and Dual Energy (DECT). SECT and DECT, allow for the differentiation of three HAP grain sizes, by progressive increase in relative density (RD). SECT, DECT, and MR enable the differentiation between natural cortical bone and synthetic HAP graft by augmentation in Effective Z and material density (MD) in HAP/Water, Calcium/Water, and Water/Calcium reconstructions, alongside the reduction in T2 relaxation time. The proposed quantification provided valuable radiological insights into the composition of HAP grafts, which may be useful in follow-up bone defect treatment.

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来源期刊
CiteScore
11.10
自引率
0.00%
发文量
133
审稿时长
42 days
期刊介绍: The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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