作为帕金森病临床标志的快速自主眨眼。

IF 4 3区医学 Q2 NEUROSCIENCES

Journal of Parkinson's disease Pub Date : 2024-01-01 DOI:10.3233/JPD-240005

Michaela Francis, Alexandra Zirra, Tahrina Haque, David Gallagher, Caroline Budu, Andrew J Lees, Anette Schrag, Alastair J Noyce, Cristina Simonet

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引用次数: 0

摘要

自发眨眼减少是公认的帕金森病（PD）特征。相比之下，对自主眨眼的研究较少，而自主眨眼可作为面部运动迟缓的可测量标记。我们对 31 名帕金森病患者和 31 名对照组进行了测试。我们拍摄了参与者在交谈和快速眨眼任务中的过程。这两项任务都进行了录像，以计算每秒眨眼的次数。帕金森病患者的眨眼次数较少。快速眨眼能准确区分不同组别，灵敏度为 77%，特异度为 71%。总之，快速眨眼可能是面部运动迟缓的一项简单而可量化的任务。

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Rapid Voluntary Blinking as a Clinical Marker of Parkinson's Disease.

Reduced spontaneous blinking is a recognized Parkinson's disease (PD) feature. In contrast, voluntary blinking has been less studied and might serve as a measurable marker of facial bradykinesia. We tested 31 PD patients and 31 controls. Participants were filmed during conversation and a rapid blinking task. Both tasks were videorecorded to count the number of blinks per second. PD patients had lower blink rates. Rapid blinking accurately discriminated between groups with 77% sensitivity and 71% specificity. To conclude, rapid blinking may be a simple and quantifiable task of facial bradykinesia.

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.