轻度认知障碍和路易体痴呆症患者在噪音幻觉测试中出现面部幻觉错误的神经心理学和神经解剖学基础。

IF 1.8 4区 心理学 Q3 CLINICAL NEUROLOGY
Ahmad Alsemari, Joseph J Boscarino
{"title":"轻度认知障碍和路易体痴呆症患者在噪音幻觉测试中出现面部幻觉错误的神经心理学和神经解剖学基础。","authors":"Ahmad Alsemari, Joseph J Boscarino","doi":"10.1080/13803395.2024.2372876","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Prior research on the Noise Pareidolia Test (NPT) has demonstrated its clinical utility in detecting patients with mild cognitive impairment and dementia due to Lewy Body Disease (LBD). However, few studies to date have investigated the neuropsychological factors underlying pareidolia errors on the NPT across the clinical spectrum of LBD. Furthermore, to our knowledge, no research has examined the relationship between cortical thickness using MRI data and NPT subscores. As such, this study sought to explore the neuropsychological and neuroanatomical factors influencing performance on the NPT utilizing the National Alzheimer's Coordinating Center Lewy Body Dementia Module.</p><p><strong>Methods: </strong>Our sample included participants with normal cognition (NC; <i>n</i> = 56), LBD with mild cognitive impairment (LBD-MCI; <i>n</i> = 97), and LBD with dementia (LBD-Dementia; <i>n</i> = 94). Archival data from NACC were retrospectively analyzed for group differences in neuropsychological test scores and cognitive and psychiatric predictors of NPT scores. Clinicoradiological correlates between NPT subscores and a small subsample of the above LBD participants were also examined.</p><p><strong>Results: </strong>Analyses revealed significant differences in NPT scores among groups. Regression analysis demonstrated that dementia severity, attention, and visuospatial processing contributed approximately 24% of NPT performance in LBD groups. Clinicoradiological analysis suggests a potential contribution of the right fusiform gyrus, but not the inferior occipital gyrus, to NPT pareidolia error scores.</p><p><strong>Conclusions: </strong>Our findings highlight the interplay of attention and visuoperceptual functions in complex pareidolia in LBD. Further investigation is needed to refine the utility of NPT scores in clinical settings, including identifying patients at risk for visual illusions and hallucinations.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuropsychological and neuroanatomical underpinnings of the face pareidolia errors on the noise pareidolia test in patients with mild cognitive impairment and dementia due to Lewy bodies.\",\"authors\":\"Ahmad Alsemari, Joseph J Boscarino\",\"doi\":\"10.1080/13803395.2024.2372876\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Prior research on the Noise Pareidolia Test (NPT) has demonstrated its clinical utility in detecting patients with mild cognitive impairment and dementia due to Lewy Body Disease (LBD). However, few studies to date have investigated the neuropsychological factors underlying pareidolia errors on the NPT across the clinical spectrum of LBD. Furthermore, to our knowledge, no research has examined the relationship between cortical thickness using MRI data and NPT subscores. As such, this study sought to explore the neuropsychological and neuroanatomical factors influencing performance on the NPT utilizing the National Alzheimer's Coordinating Center Lewy Body Dementia Module.</p><p><strong>Methods: </strong>Our sample included participants with normal cognition (NC; <i>n</i> = 56), LBD with mild cognitive impairment (LBD-MCI; <i>n</i> = 97), and LBD with dementia (LBD-Dementia; <i>n</i> = 94). Archival data from NACC were retrospectively analyzed for group differences in neuropsychological test scores and cognitive and psychiatric predictors of NPT scores. Clinicoradiological correlates between NPT subscores and a small subsample of the above LBD participants were also examined.</p><p><strong>Results: </strong>Analyses revealed significant differences in NPT scores among groups. Regression analysis demonstrated that dementia severity, attention, and visuospatial processing contributed approximately 24% of NPT performance in LBD groups. Clinicoradiological analysis suggests a potential contribution of the right fusiform gyrus, but not the inferior occipital gyrus, to NPT pareidolia error scores.</p><p><strong>Conclusions: </strong>Our findings highlight the interplay of attention and visuoperceptual functions in complex pareidolia in LBD. Further investigation is needed to refine the utility of NPT scores in clinical settings, including identifying patients at risk for visual illusions and hallucinations.</p>\",\"PeriodicalId\":15382,\"journal\":{\"name\":\"Journal of clinical and experimental neuropsychology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical and experimental neuropsychology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1080/13803395.2024.2372876\",\"RegionNum\":4,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical and experimental neuropsychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1080/13803395.2024.2372876","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

研究目的之前关于噪声幻觉测试(NPT)的研究表明,该测试在检测路易体病(LBD)导致的轻度认知障碍和痴呆患者方面具有临床实用性。然而,迄今为止,很少有研究调查了在路易体病的临床范围内,NPT 中出现幻听错误的神经心理学因素。此外,据我们所知,还没有研究利用核磁共振成像数据检查皮层厚度与 NPT 子分数之间的关系。因此,本研究试图利用国家阿尔茨海默氏症协调中心路易体痴呆模块,探讨影响 NPT 表现的神经心理学和神经解剖学因素:我们的样本包括认知正常者(NC;n = 56)、伴有轻度认知障碍的路易体痴呆者(LBD-MCI;n = 97)和伴有痴呆的路易体痴呆者(LBD-Dementia;n = 94)。我们对 NACC 的档案数据进行了回顾性分析,以了解神经心理学测试评分的组间差异以及 NPT 评分的认知和精神预测因素。此外,还研究了 NPT 分值与上述枸杞多糖症患者的一小部分子样本之间的临床放射学相关性:结果:分析表明,各组之间的 NPT 分数存在明显差异。回归分析表明,痴呆严重程度、注意力和视觉空间处理能力约占枸杞多糖症组 NPT 成绩的 24%。临床放射学分析表明,右侧纺锤形回(而非枕下回)对NPT视差错误评分有潜在贡献:我们的研究结果凸显了在枸杞多糖症的复杂性视幻觉中注意力和视觉感知功能的相互作用。还需要进一步研究来完善NPT评分在临床环境中的实用性,包括识别有视觉错觉和幻觉风险的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuropsychological and neuroanatomical underpinnings of the face pareidolia errors on the noise pareidolia test in patients with mild cognitive impairment and dementia due to Lewy bodies.

Objective: Prior research on the Noise Pareidolia Test (NPT) has demonstrated its clinical utility in detecting patients with mild cognitive impairment and dementia due to Lewy Body Disease (LBD). However, few studies to date have investigated the neuropsychological factors underlying pareidolia errors on the NPT across the clinical spectrum of LBD. Furthermore, to our knowledge, no research has examined the relationship between cortical thickness using MRI data and NPT subscores. As such, this study sought to explore the neuropsychological and neuroanatomical factors influencing performance on the NPT utilizing the National Alzheimer's Coordinating Center Lewy Body Dementia Module.

Methods: Our sample included participants with normal cognition (NC; n = 56), LBD with mild cognitive impairment (LBD-MCI; n = 97), and LBD with dementia (LBD-Dementia; n = 94). Archival data from NACC were retrospectively analyzed for group differences in neuropsychological test scores and cognitive and psychiatric predictors of NPT scores. Clinicoradiological correlates between NPT subscores and a small subsample of the above LBD participants were also examined.

Results: Analyses revealed significant differences in NPT scores among groups. Regression analysis demonstrated that dementia severity, attention, and visuospatial processing contributed approximately 24% of NPT performance in LBD groups. Clinicoradiological analysis suggests a potential contribution of the right fusiform gyrus, but not the inferior occipital gyrus, to NPT pareidolia error scores.

Conclusions: Our findings highlight the interplay of attention and visuoperceptual functions in complex pareidolia in LBD. Further investigation is needed to refine the utility of NPT scores in clinical settings, including identifying patients at risk for visual illusions and hallucinations.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.20
自引率
4.50%
发文量
52
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical and Experimental Neuropsychology ( JCEN) publishes research on the neuropsychological consequences of brain disease, disorders, and dysfunction, and aims to promote the integration of theories, methods, and research findings in clinical and experimental neuropsychology. The primary emphasis of JCEN is to publish original empirical research pertaining to brain-behavior relationships and neuropsychological manifestations of brain disease. Theoretical and methodological papers, critical reviews of content areas, and theoretically-relevant case studies are also welcome.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信