白腐霉菌 PP17-20 的磷脂酰胆碱和神经酰胺衍生物。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-06-28 DOI:10.1080/10286020.2024.2368834

Phongphan Jantaharn, Audomsak Churat, Sirirat Juanan, Ek Sangvichien, Wiyada Mongkolthanaruk, Nuttika Suwannasai, Thanaset Senawong, Sirirath McCloskey

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引用次数: 0

摘要

从白腐真菌微孢子虫 PP17-20 的培养物中分离出了未被描述的磷脂酰胆碱（1）以及 12 种已知化合物。在这项工作中，该真菌在酵母-麦芽提取物培养基中进行培养，以探索活性化合物的生产。根据光谱和 HRESIMS 数据阐明了化学结构。评估了几种分离化合物对 A549 和 MCF-7 癌细胞株的抗增殖活性。

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Phosphatidylcholine and ceramide derivatives from white rot fungus Microporus xanthropus PP17-20.

The undescribed phosphatidylcholine (1), along with twelve known compounds, was isolated from the cultures of white rot fungus Microporus xanthropus PP17-20. In this work the fungus was cultivated in Yeast-Malt extract medium to explore active compound production. The chemical structures were elucidated on the basis of spectroscopic and HRESIMS data. Several isolated compounds were evaluated for anti-proliferative activity against A549 and MCF-7 cancer cell lines.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.