从Areca catechu果皮中提取的双哌啶生物碱。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-06-30 DOI:10.1080/10286020.2024.2372383

Xia Zhang, Fang-Xin Wang, Zi-Wei Li, Song Wang, Shi-Qing Zhang, Min Song, Xiao-Qi Zhang

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引用次数: 0

摘要

从儿茶属植物的果皮中分离出了四种新的生物碱，即儿茶碱 A-D（1-4）。化合物 1 是一种不常见的哌啶-吡啶混合生物碱，而化合物 2-4 则是双哌啶生物碱。通过紫外光谱、红外光谱、HRESIMS 和核磁共振光谱分析阐明了它们的结构。分子对接分析表明，化合物 3 与 GABAA 受体的结合亲和力最佳，表明其具有潜在的抗癫痫活性。

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Bis-piperidine alkaloids from the peels of Areca catechu.

Four new alkaloids, arecatines A-D (1-4), were isolated from the peels of Areca catechu. Compound 1 is an unusual piperidine-pyridine hybrid alkaloid, whereas compounds 2-4 feature bis-piperidine alkaloids. Their structures were elucidated by UV, IR, HRESIMS, and NMR spectra analysis. The molecular docking analysis indicated that compound 3 exhibited the best binding affinity with the GABA_A receptor, indicating its potential anti-epilepsy activity.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.