泛素化在骨质疏松症发生和发展中的作用(综述)。

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI:10.3892/ijmm.2024.5392
Xiaoxia Fan, Rong Zhang, Guocai Xu, Peiyun Fan, Wei Luo, Chunmei Cai, Ri-Li Ge
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引用次数: 0

摘要

泛素(Ub)-蛋白酶体系统(UPS)在维持蛋白质平衡方面发挥着关键作用,并具有调节各种细胞过程(包括骨骼细胞分化和骨平衡)的功能。Ub 连接酶 E3 促进 Ub 向靶蛋白(尤其是转录因子)转移,从而调节骨细胞的增殖、分化和存活以及骨形成。反过来,去泛素化酶将 Ub 从修饰的底物蛋白中清除,以协调骨重塑。泛素化调控异常会导致骨细胞分化紊乱,进而影响骨平衡,导致骨质疏松症。本综述讨论了 UPS 在骨重塑中的作用和机制。然而,UPS 在骨重塑过程中的具体机制仍未完全清楚,有待进一步研究。研究 UPS 的作用机制可以为预防和治疗骨质疏松症提供新的思路和方法。此外,本综述还讨论了临床上最常用的针对泛素化过程的骨质疏松症药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of ubiquitination in the occurrence and development of osteoporosis (Review).

The ubiquitin (Ub)‑proteasome system (UPS) plays a pivotal role in maintaining protein homeostasis and function to modulate various cellular processes including skeletal cell differentiation and bone homeostasis. The Ub ligase E3 promotes the transfer of Ub to the target protein, especially transcription factors, to regulate the proliferation, differentiation and survival of bone cells, as well as bone formation. In turn, the deubiquitinating enzyme removes Ub from modified substrate proteins to orchestrate bone remodeling. As a result of abnormal regulation of ubiquitination, bone cell differentiation exhibits disorder and then bone homeostasis is affected, consequently leading to osteoporosis. The present review discussed the role and mechanism of UPS in bone remodeling. However, the specific mechanism of UPS in the process of bone remodeling is still not fully understood and further research is required. The study of the mechanism of action of UPS can provide new ideas and methods for the prevention and treatment of osteoporosis. In addition, the most commonly used osteoporosis drugs that target ubiquitination processes in the clinic are discussed in the current review.

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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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