NUAK：永远不要低估激酶。

IF 5.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Essays in biochemistry Pub Date : 2024-11-18 DOI:10.1042/EBC20240005

George L Skalka, Declan Whyte, Dominika Lubawska, Daniel J Murphy

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引用次数: 0

摘要

NUAK1和NUAK2属于激酶家族，与AMP激活蛋白激酶（AMPK）复合物的催化α亚基有关。尽管NUAKs是由肿瘤抑制激酶LKB1激活的，但它们都表现出一系列有利于肿瘤发生和发展的活性。在此，我们回顾了 NUAKs 在结构和功能上的相似性，它们在基因、转录本和蛋白质水平上的调控，并结合信号转导途径和受每种或两种 NUAKs 调控的生物活性，讨论了它们对特定下游靶点的磷酸化作用。

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NUAK: never underestimate a kinase.

NUAK1 and NUAK2 belong to a family of kinases related to the catalytic α-subunits of the AMP-activated protein kinase (AMPK) complexes. Despite canonical activation by the tumour suppressor kinase LKB1, both NUAKs exhibit a spectrum of activities that favour tumour development and progression. Here, we review similarities in structure and function of the NUAKs, their regulation at gene, transcript and protein level, and discuss their phosphorylation of specific downstream targets in the context of the signal transduction pathways and biological activities regulated by each or both NUAKs.

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来源期刊

Essays in biochemistry 生物-生化与分子生物学

CiteScore

10.50

自引率

0.00%

发文量

105

审稿时长

>12 weeks

期刊介绍： Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immersed in the subject, each article is an up-to-date, self-contained summary of the topic. Bridging the gap between the latest research and established textbooks, Essays in Biochemistry will tell you what you need to know to begin exploring the field, as each article includes the top take-home messages as summary points. Each issue of the journal is guest edited by a key opinion leader in the area, and whether you are continuing your studies or moving into a new research area, the Journal gives a complete picture in one place. Essays in Biochemistry is proud to publish Understanding Biochemistry, an essential online resource for post-16 students, teachers and undergraduates. Providing up-to-date overviews of key concepts in biochemistry and the molecular biosciences, the Understanding Biochemistry issues of Essays in Biochemistry are published annually in October.