肾上腺皮质肿瘤中血管内皮生长因子和内皮生长因子的表达及其与组织病理学预后参数的关系。

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2024-08-08 Epub Date: 2024-06-29 DOI:10.1507/endocrj.EJ24-0032
Melia Karaköse, Mustafa Can, Muhammet Kocabaş, Hacı Hasan Esen, Mustafa Kulaksızoğlu, Feridun Karakurt
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引用次数: 0

摘要

本研究旨在确定肾上腺皮质肿瘤中血管内皮生长因子(VEGF)和内皮生长因子(endocan)的组织表达及其相关因素。研究对象包括6名肾上腺皮质腺瘤(ACA)患者、7名肾上腺皮质癌(ACC)患者和13名肾上腺皮质正常的对照组患者。血管内皮生长因子(VEGF)和内皮生长因子(endocan)的表达状况是根据细胞染色比例确定的,染色范围从阴性(完全不染色)到强阳性。在ACA组的6名受试者中,有1人(16.7%)检测到血管内皮生长因子的表达;在ACC组的7名受试者中,有6人(85.7%)检测到血管内皮生长因子的表达。对照组的所有受试者均未检测到血管内皮生长因子的表达。ACA 组 6 名受试者中有 6 人(100%)检测到内切酶表达,ACC 组 7 名受试者中有 7 人(100%)检测到内切酶表达,而对照组 13 名受试者中只有 4 人(30.7%)检测到内切酶表达。血管内皮生长因子在 ACC 受试者中高频率表达,在 ACA 受试者中低频率表达,但在正常肾上腺皮质组织受试者中却没有表达。虽然内切酶在 ACC 和 ACA 患者中的表达频率较高,但在正常肾上腺皮质组织中也有表达。ACC受试者中表达内切酶的细胞百分比也明显高于ACA和正常肾上腺皮质受试者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters.

The aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them. The study included 6 subjects with adrenocortical adenoma (ACA), 7 subjects with adrenocortical carcinoma (ACC), and 13 control subjects with a normal adrenal cortex. The status of VEGF and endocan expression was determined by the proportions of cells staining on a scale ranging from negative (not staining at all) to strongly positive. VEGF expression was detected in 1 (16.7%) of 6 subjects in the ACA group and in 6 (85.7%) of 7 subjects in the ACC group. VEGF expression was not detected in any of the subjects in the control group. Endocan expression was detected in 6 (100%) of 6 subjects in the ACA group and in 7 (100%) of 7 subjects in the ACC group, while it was detected in only 4 (30.7%) of 13 subjects in the control group. VEGF was expressed with a high frequency in subjects with ACC and with a low frequency in subjects with ACA, but it was not expressed in subjects with normal adrenal cortex tissue. Although endocan was expressed with a higher frequency in subjects with ACC and ACA, it was also expressed in subjects with normal adrenal cortex tissue. The percentage of cells expressed endocan in subjects with ACC was also significantly higher than in subjects with both ACA and normal adrenal cortex.

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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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