Qinyi Zhou, Yuan Li, Zhixiang Zhou, Yiren Zhou, Yizhou Liu, Wang Liu, Xiaofeng Ma
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引用次数: 0
摘要
三方基序蛋白家族成员 65（TRIM65）属于三方基序（TRIM）蛋白家族。其典型结构包括 N 端高度保守的 RING、B-Box motif 和线圈结构域，以及 C 端可变的 SPRY 结构域。TRIM65 是一种 E3 泛素连接酶，通过泛素化途径参与生理和病理过程，包括细胞内信号转导、蛋白质降解、细胞增殖、凋亡、癌变、自噬和表型转化。有证据表明，TRIM65 在疾病（包括多系统肿瘤、神经退行性疾病、免疫系统疾病和炎症性疾病）中发挥着显著而不明显的作用。本综述主要阐述TRIM65与疾病的关系及其致病机制，为TRIM65可能成为疾病的致病靶点提供理论依据，并探讨TRIM65未来可能的研究方向及其面临的挑战。
Tripartite-motif protein family member 65 (TRIM65) belongs to the tripartite motif (TRIM) protein family. Its typical structure consists of the RING, B-Box motif, and coiled-coil domains, which are highly conserved at the N-terminus and the variable SPRY domain at the C-terminus. TRIM65 is an E3 ubiquitin ligase that participates in physiological and pathological processes through the ubiquitination pathway, including intracellular signal transduction, protein degradation, cell proliferation, apoptosis, carcinogenesis, autophagy, and phenotypic transformation. Evidence shows that TRIM65 plays a remarkable and obscure role in diseases, including multisystem tumours, neurodegenerative diseases, immune system diseases, and inflammatory diseases. This review is devoted to elaborating on the relationship between TRIM65 and diseases and its pathogenic mechanism, providing a theoretical basis for TRIM65 as a possible pathogenic target of diseases and exploring the possible future research direction of TRIM65 and the challenges it may face.
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Aims & Scope
Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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