癌症通过淋巴和血管转移。

IF 4.2 3区 医学 Q2 ONCOLOGY
Clinical & Experimental Metastasis Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI:10.1007/s10585-024-10288-0
Stanley P Leong, Marlys H Witte
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引用次数: 0

摘要

癌细胞是通过淋巴管转移到原发部位,还是通过血管直接进入血液循环转移到远处部位,目前仍在深入研究中。在这篇综述文章中,我们将跟踪癌细胞转移到前哨淋巴结并扩散到远处部位的过程。我们强调癌症的异质性和微环境是癌症转移的主要决定因素。研究发现,多种分子与转移的复杂过程有关。根据大量的前哨淋巴结数据,我们有理由得出结论,癌细胞在某些情况下可能会通过血管转移,但在大多数情况下,它们会利用前哨淋巴结作为主要通道,进入血液循环,向远处转移。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cancer metastasis through the lymphatic versus blood vessels.

Cancer metastasis through the lymphatic versus blood vessels.

Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the circulation is still under intense study. In this review article, we follow the journey of cancer cells metastasizing to the sentinel lymph nodes and beyond to the distant sites. We emphasize cancer heterogeneity and microenvironment as major determinants of cancer metastasis. Multiple molecules have been found to be associated with the complicated process of metastasis. Based on the large sentinel lymph node data, it is reasonable to conclude that cancer cells may metastasize through the blood vessels in some cases but in most cases, they use the sentinel lymph nodes as the major gateway to enter the circulation to distant sites.

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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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