泛 RAF:MEK 分子胶占据中心位置。

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-07-01 DOI:10.1158/2159-8290.CD-24-0539

Matthew J Hangauer, Jorge Silvio Gutkind, Fleur M Ferguson

引用次数: 0

摘要

在本期杂志中，Ryan 及其同事介绍了泛 RAF:MEK 分子胶的临床前开发情况，该分子胶在 Ras/Raf/MAPK 通路驱动的肿瘤异种移植模型中具有卓越的疗效、脑穿透性和耐受性。请参见 Ryan 等人的相关文章，第 1190 页（1）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Pan-RAF:MEK Molecular Glues Take Center Stage.

In this issue, Ryan and colleagues describe the preclinical development of a pan-RAF:MEK molecular glue with superior efficacy, brain penetrance, and tolerability in xenograft models of Ras/Raf/MAPK pathway-driven tumors. See related article by Ryan et al., p. 1190 (1).

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.