Truong Nguyen Duy , Hoang Le Huy , Quyen Đao Thanh , Hoai Ngo Thi , Hanh Ngo Thi Minh , Manh Nguyen Dang , Song Le Huu , Trung Ngo Tat
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Real-time PCR assessed infection rates and bacterial loads in CRC tissues.</p></div><div><h3>Results</h3><p><em>B. fragilis</em> infection was notably higher in CRC tissues (51.6 %) than polyps (9.4 %), with a fivefold higher relative load. Positive associations were found in stages II and III, indicating a fivefold increase in CRC progression risk. <em>F. nucleatum</em> infection rates were significantly higher in CRC tissues (55.2 %) than in polyps (10.5 %). In stage II, the infection rate exceeded that in adjacent tissues. The relative load of <em>F. nucleatum</em> was higher in stage III than in stages I and II. Positive <em>F. nucleatum</em> patients had a 3.2 times higher risk of CRC progression.</p></div><div><h3>Conclusion</h3><p>These findings suggest associations between loading of <em>F. nucleatum</em> or/and <em>B. fragilis</em> with the advanced stages of CRC.</p></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients\",\"authors\":\"Truong Nguyen Duy , Hoang Le Huy , Quyen Đao Thanh , Hoai Ngo Thi , Hanh Ngo Thi Minh , Manh Nguyen Dang , Song Le Huu , Trung Ngo Tat\",\"doi\":\"10.1016/j.anaerobe.2024.102880\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Colorectal cancer (CRC) is a significant global health concern, and understanding the role of specific bacterial infections in its development and progression is of increasing interest. This cross-sectional study investigated the associations between <em>Bacteroides fragilis</em> (<em>B. fragilis</em>) and <em>Fusobacterium nucleatum</em> (<em>F. nucleatum</em>) infections and Vietnamese CRC patients.</p></div><div><h3>Methods</h3><p>192 patients with either polyps or CRC at varying stages were recruited from May 2017 to December 2020. Real-time PCR assessed infection rates and bacterial loads in CRC tissues.</p></div><div><h3>Results</h3><p><em>B. fragilis</em> infection was notably higher in CRC tissues (51.6 %) than polyps (9.4 %), with a fivefold higher relative load. Positive associations were found in stages II and III, indicating a fivefold increase in CRC progression risk. <em>F. nucleatum</em> infection rates were significantly higher in CRC tissues (55.2 %) than in polyps (10.5 %). In stage II, the infection rate exceeded that in adjacent tissues. The relative load of <em>F. nucleatum</em> was higher in stage III than in stages I and II. Positive <em>F. nucleatum</em> patients had a 3.2 times higher risk of CRC progression.</p></div><div><h3>Conclusion</h3><p>These findings suggest associations between loading of <em>F. nucleatum</em> or/and <em>B. fragilis</em> with the advanced stages of CRC.</p></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1075996424000635\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1075996424000635","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
摘要
背景：结肠直肠癌（CRC）是全球关注的重大健康问题，了解特定细菌感染在其发生和发展中的作用越来越受到关注。这项横断面研究调查了脆弱拟杆菌（B. fragilis）和核酸镰刀菌（F. nucleatum）感染与越南 CRC 患者之间的关联。方法：2017 年 5 月至 2020 年 12 月期间，招募了 192 名不同阶段的息肉或 CRC 患者。实时 PCR 评估了 CRC 组织中的感染率和细菌量：CRC组织中B. fragilis感染率（51.6%）明显高于息肉（9.4%），相对载量高出5倍。在 II 期和 III 期发现了正相关，表明 CRC 进展风险增加了五倍。CRC 组织中的 F. nucleatum 感染率（55.2%）明显高于息肉（10.5%）。在二期，感染率超过了邻近组织。在 III 期，F. nucleatum 的相对载量高于 I 期和 II 期。核酸桿菌陽性患者的 CRC 發病風險高出 3.2 倍：这些研究结果表明，F. nucleatum或/和B. fragilis的载量与CRC的晚期阶段有关。
Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients
Background
Colorectal cancer (CRC) is a significant global health concern, and understanding the role of specific bacterial infections in its development and progression is of increasing interest. This cross-sectional study investigated the associations between Bacteroides fragilis (B. fragilis) and Fusobacterium nucleatum (F. nucleatum) infections and Vietnamese CRC patients.
Methods
192 patients with either polyps or CRC at varying stages were recruited from May 2017 to December 2020. Real-time PCR assessed infection rates and bacterial loads in CRC tissues.
Results
B. fragilis infection was notably higher in CRC tissues (51.6 %) than polyps (9.4 %), with a fivefold higher relative load. Positive associations were found in stages II and III, indicating a fivefold increase in CRC progression risk. F. nucleatum infection rates were significantly higher in CRC tissues (55.2 %) than in polyps (10.5 %). In stage II, the infection rate exceeded that in adjacent tissues. The relative load of F. nucleatum was higher in stage III than in stages I and II. Positive F. nucleatum patients had a 3.2 times higher risk of CRC progression.
Conclusion
These findings suggest associations between loading of F. nucleatum or/and B. fragilis with the advanced stages of CRC.
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