[螯合素在多囊卵巢综合征中的研究进展]。

Q3 Medicine
生理学报 Pub Date : 2024-06-25
Xiao-Juan Zhu, Hang Qiu, Sheng-Lan Liu, Wei Dai, Hai-Bo Hu, Hao Huang
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引用次数: 0

摘要

作为一种多功能脂肪因子,螯合素通过内分泌和旁分泌方式在各种病理生理过程中发挥着重要作用。它可以与三种已知的受体(ChemR23、GPR1 和 CCRL2)结合,参与能量代谢、葡萄糖和脂质代谢以及炎症,尤其是代谢性疾病。多囊卵巢综合征(PCOS)是最常见的内分泌疾病之一,严重影响育龄妇女的正常生活。多囊卵巢综合征患者血清中的螯合素水平明显升高,卵巢中的螯合素表达量也很高。越来越多的研究表明,螯合素通过影响肥胖、胰岛素抵抗、高雄激素、氧化应激和炎症反应,参与了多囊卵巢综合征的发生和发展。本文主要综述了螯合素蛋白的产生、亚型、功能和受体,从代谢、生殖和炎症等角度总结和探讨了螯合素蛋白在多囊卵巢综合征中的研究现状,为多囊卵巢综合征的临床诊治提供理论依据和参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Research progress of chemerin in polycystic ovary syndrome].

As a multifunctional adipokine, chemerin plays a crucial role in various pathophysiological processes through endocrine and paracrine manner. It can bind to three known receptors (ChemR23, GPR1 and CCRL2) and participate in energy metabolism, glucose and lipid metabolism, and inflammation, especially in metabolic diseases. Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases, which seriously affects the normal life of women of childbearing age. Patients with PCOS have significantly increased serum levels of chemerin and high expression of chemerin in their ovaries. More and more studies have shown that chemerin is involved in the occurrence and development of PCOS by affecting obesity, insulin resistance, hyperandrogenism, oxidative stress and inflammatory response. This article mainly reviews the production, subtypes, function and receptors of chemerin protein, summarizes and discusses the research status of chemerin protein in PCOS from the perspectives of metabolism, reproduction and inflammation, and provides theoretical basis and reference for the clinical diagnosis and treatment of PCOS.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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