去透明细胞分化型肾细胞癌--新的治疗目标

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2024-06-27 DOI:10.1038/s41585-024-00911-w

Keith A. Lawson, W. Marston Linehan

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引用次数: 0

摘要

重新编程的新陈代谢长期以来一直被认为是肾癌进展的驱动因素，这促使人们努力开发针对这种疾病的新陈代谢靶向疗法。有证据进一步阐明了与侵袭性疾病相关的代谢表型，从而扩大了从代谢根源攻击这些肿瘤的潜在靶点空间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

De-clear cell differentiated renal cell carcinoma — a new therapeutic target

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De-clear cell differentiated renal cell carcinoma — a new therapeutic target

Reprogrammed metabolism has been long recognized as a driver of kidney cancer progression, prompting efforts to develop metabolic targeted therapies against this disease. Evidence offers further clarity on the metabolic phenotypes associated with aggressive disease, expanding the potential target space for attacking these tumours at their metabolic roots.

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.