Andrés M. Treviño-Alvarez, Tomás Cabeza de Baca, Emma J. Stinson, Marci E. Gluck, Paolo Piaggi, Susanne B. Votruba, Jonathan Krakoff, Douglas C. Chang
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Measurements included body composition by dual-energy x-ray absorptiometry scan, ad libitum energy intake by a vending machine paradigm over 3 days, and 24-h EE in a whole-room indirect calorimeter.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Lower bicarbonate, higher AG, and higher CAG were correlated with higher waist and thigh circumferences, body fat (percentage), fat mass, triglycerides, and lower high-density lipoprotein cholesterol. Acid accumulation markers were correlated with higher total energy (CAG partial <i>r</i> = 0.17; <i>p</i> = 0.02), fat (CAG partial <i>r</i> = 0.17; <i>p</i> = 0.02), protein intake (CAG partial <i>r</i> = 0.20; <i>p</i> = 0.006), and 24-h EE (CAG partial <i>r</i> = 0.24; <i>p</i> = 0.0007). A mediation analysis of CAG and total energy intake found that 24-h EE was a partial mediator (40%), but the association remained significant (β = 0.15; <i>p</i> < 0.0001).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>In healthy individuals, acid accumulation was associated with an unfavorable metabolic phenotype; higher 24-h EE; and increased total energy, fat, and protein intake. 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引用次数: 0
摘要
研究目的本研究旨在探讨酸积累（较低的血浆碳酸氢盐、较高的阴离子间隙[AG]和校正阴离子间隙[CAG]）与代谢参数、食物摄入量和 24 小时能量消耗（EE）之间的相关性：对估计肾小球滤过率大于 60 mL/min/1.73 m2 的 286 名健康成年人进行了酸积累测量。测量包括双能 X 射线吸收扫描的身体成分、自动售货机范例的 3 天自由能量摄入量以及全室间接热量计的 24 小时能量消耗：结果：较低的碳酸氢盐、较高的 AG 和较高的 CAG 与较高的腰围和大腿围、体脂（百分比）、脂肪量、甘油三酯和较低的高密度脂蛋白胆固醇相关。酸积累标记物与较高的总能量（CAG 部分 r = 0.17；p = 0.02）、脂肪（CAG 部分 r = 0.17；p = 0.02）、蛋白质摄入量（CAG 部分 r = 0.20；p = 0.006）和 24 小时 EE（CAG 部分 r = 0.24；p = 0.0007）相关。对 CAG 和总能量摄入量的中介分析发现，24 小时 EE 是一个部分中介（40%），但两者之间的关系仍然显著（β = 0.15；p 结论：CAG 和总能量摄入量之间的中介分析结果表明，24 小时 EE 是一个部分中介（40%），但两者之间的关系仍然显著（β = 0.15；p）：在健康人中，酸积累与不利的代谢表型、较高的 24 小时 EE 以及总能量、脂肪和蛋白质摄入量增加有关。酸积累标志物作为较高膳食酸负荷（如来自蛋白质）的假定标志物，可能会影响能量平衡生理学，导致体重增加。
Acid accumulation is associated with metabolic alterations; higher energy, fat, and protein intake; and energy expenditure
Objective
The objective of this study was to study how acid accumulation (lower plasma bicarbonate and higher anion gap [AG] and corrected anion gap [CAG]) correlates with metabolic parameters, food intake, and 24-h energy expenditure (EE).
Methods
Acid accumulation was measured in 286 healthy adults with estimated glomerular filtration rate > 60 mL/min/1.73 m2. Measurements included body composition by dual-energy x-ray absorptiometry scan, ad libitum energy intake by a vending machine paradigm over 3 days, and 24-h EE in a whole-room indirect calorimeter.
Results
Lower bicarbonate, higher AG, and higher CAG were correlated with higher waist and thigh circumferences, body fat (percentage), fat mass, triglycerides, and lower high-density lipoprotein cholesterol. Acid accumulation markers were correlated with higher total energy (CAG partial r = 0.17; p = 0.02), fat (CAG partial r = 0.17; p = 0.02), protein intake (CAG partial r = 0.20; p = 0.006), and 24-h EE (CAG partial r = 0.24; p = 0.0007). A mediation analysis of CAG and total energy intake found that 24-h EE was a partial mediator (40%), but the association remained significant (β = 0.15; p < 0.0001).
Conclusions
In healthy individuals, acid accumulation was associated with an unfavorable metabolic phenotype; higher 24-h EE; and increased total energy, fat, and protein intake. Acid accumulation markers, as putative markers of higher dietary acid load (e.g., from protein), may affect energy balance physiology promoting weight gain.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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